6LFL

Crystal structure of a class A GPCR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	C-X-C chemokine receptor type 2,GlgA glycogen synthase,C-X-C chemokine receptor type 2	polymer	502	56694.9	1	UniProt (P25025) UniProt (Q9V2J8) Pfam (PF00001) Pfam (PF13692) In PDB	Homo sapiens (Human)	CXCR-2,CDw128b,GRO/MGSA receptor,High affinity interleukin-8 receptor B,IL-8R B,IL-8 receptor type 2,Glycogen synthase,CXCR-2,CDw128b,GRO/MGSA receptor,High affinity interleukin-8 receptor B,IL-8R B,IL-8 receptor type 2
2	A	4-[[3,4-bis(oxidanylidene)-2-[[(1~{R})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{N},~{N}-dimethyl-3-oxidanyl-pyridine-2-carboxamide	non-polymer		426.5	1	Chemie (EBX)

Sequence modifications

A: 37 - 241 (UniProt: P25025)

PDB	External Database	Details
Trp 135	Leu 135	engineered mutation

A: 1001 - 1196 (UniProt: Q9V2J8)
A: 244 - 344 (UniProt: P25025)

PDB	External Database	Details
Glu 249	Ala 249	engineered mutation
Ala 303	Gly 303	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	56694.9
Non-Polymers*	Number of molecules	1
	Total formula weight	426.5
All*	Total formula weight	57121.3

*Water molecules are not included.