6LES

3D domain-swapped dimer of the maltose-binding protein fused to a fragment of the focal adhesion kinase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, X, Y)	Maltose/maltodextrin-binding periplasmic protein,Focal adhesion kinase 1	polymer	397	43853.6	4	UniProt (P0AEX9) UniProt (Q05397) Pfam (PF01547)	Escherichia coli (strain K12)	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP,FADK 1,Focal adhesion kinase-related nonkinase,FRNK,Protein phosphatase 1 regulatory subunit 71,PPP1R71,Protein-tyrosine kinase 2,p125FAK,pp125FAK
2	E, F (B, Y)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	G, H, I, J (A, B, X, Y)	water	water		18.0	428	Chemie (HOH)

Sequence modifications

A, B, X, Y: 2 - 367 (UniProt: P0AEX9)

PDB	External Database	Details
Met 1	-	initiating methionine
Ala 83	Asp 108	engineered mutation
Ala 84	Lys 109	engineered mutation
Ala 173	Glu 198	engineered mutation
Ala 174	Asn 199	engineered mutation
Ala 240	Lys 265	engineered mutation
Ala 360	Glu 385	engineered mutation
Ala 363	Lys 388	engineered mutation
Ala 364	Asp 389	engineered mutation
Asn 368	-	linker
Ala 369	-	linker

A, B, X, Y: 370 - 397 (UniProt: Q05397)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	175414.4
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	175606.5

*Water molecules are not included.