6LD3

Zika NS5 polymerase domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	RNA-directed RNA polymerase NS5	polymer	645	74904.2	1	UniProt (A0A024B7W1) Pfam (PF00972) Pfam (PF20483) In PDB	Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV)	NS5
2	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	A	2,4-dimethoxy-5-thiophen-2-yl-benzoic acid	non-polymer		264.3	1	Chemie (G8O)
4	A	benzenesulfonamide	non-polymer		157.2	1	Chemie (FB2)
5		water	water		18.0	215	Chemie (HOH)

Sequence modifications

A: 270 - 891 (UniProt: A0A024B7W1)

PDB	External Database	Details
Met 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
Ser 254	-	expression tag
Ser 255	-	expression tag
Gly 256	-	expression tag
Val 257	-	expression tag
Asp 258	-	expression tag
Leu 259	-	expression tag
Gly 260	-	expression tag
Thr 261	-	expression tag
Glu 262	-	expression tag
Asn 263	-	expression tag
Leu 264	-	expression tag
Tyr 265	-	expression tag
Phe 266	-	expression tag
Gln 267	-	expression tag
Ser 268	-	expression tag
Met 269	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	74904.2
Non-Polymers*	Number of molecules	4
	Total formula weight	552.3
All*	Total formula weight	75456.5

*Water molecules are not included.