6LCB
Crystal structure of human Dishevelled1 PDZ domain with its inhibitor NPL3009
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Segment polarity protein dishevelled homolog DVL-1 | polymer | 102 | 10771.1 | 1 | UniProt (O14640) Pfam (PF00595) | Homo sapiens (Human) | Dishevelled-1,DSH homolog 1 |
| 2 | B (A) | 2-[[3-[(2E)-2-[1,3-bis(oxidanylidene)-1-phenyl-butan-2-ylidene]hydrazinyl]phenyl]sulfonylamino]benzoic acid | non-polymer | 465.5 | 1 | Chemie (E83) | |||
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D (A) | water | water | 18.0 | 43 | Chemie (HOH) |
Sequence modifications
A: 246 - 340 (UniProt: O14640)
| PDB | External Database | Details |
|---|---|---|
| Gly 239 | - | expression tag |
| Pro 240 | - | expression tag |
| Leu 241 | - | expression tag |
| Gly 242 | - | expression tag |
| Ser 243 | - | expression tag |
| Asp 244 | - | expression tag |
| His 245 | - | expression tag |
| Ala 338 | Cys 338 | engineered mutation |
| Thr 339 | Trp 339 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 10771.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 561.5 | |
| All* | Total formula weight | 11332.6 |
