6L37

X-ray structure of human PPARalpha ligand binding domain-GW9662-ciprofibrate co-crystals obtained by delipidation and co-crystallization

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Peroxisome proliferator-activated receptor alpha	polymer	273	30856.1	2	UniProt (Q07869) Pfam (PF00104)	Homo sapiens
2	C, D, E, G, H... (A, B)	2-chloro-5-nitro-N-phenylbenzamide	non-polymer		276.7	6	Chemie (GW9)
3	F, J (A, B)	2-{4-[(1S)-2,2-dichlorocyclopropyl]phenoxy}-2-methylpropanoic acid	non-polymer		289.2	2	Chemie (C5F)

Sequence modifications

A, B: 200 - 468 (UniProt: Q07869)

PDB	External Database	Details
Gly 196	-	expression tag
Ser 197	-	expression tag
His 198	-	expression tag
Met 199	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61712.1
Non-Polymers*	Number of molecules	8
	Total formula weight	2238.4
All*	Total formula weight	63950.5

*Water molecules are not included.