Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue GW9 A 501 |
| Chain | Residue |
| A | ILE241 |
| A | CYS276 |
| A | THR279 |
| A | LEU331 |
| A | VAL332 |
| A | ILE339 |
| A | GW9502 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GW9 A 502 |
| Chain | Residue |
| A | THR253 |
| A | LEU254 |
| A | CYS275 |
| A | ALA333 |
| A | TYR334 |
| A | GW9501 |
| A | ALA250 |
| A | GLU251 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue GW9 A 503 |
| Chain | Residue |
| A | LEU254 |
| A | LYS257 |
| A | LEU258 |
| A | ASN261 |
| A | HIS274 |
| A | CYS275 |
| A | CYS278 |
| A | ALA455 |
| A | HIS457 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue C5F A 504 |
| Chain | Residue |
| A | PHE273 |
| A | CYS276 |
| A | GLN277 |
| A | SER280 |
| A | TYR314 |
| A | HIS440 |
| A | ILE447 |
| A | ALA454 |
| A | LEU456 |
| A | TYR464 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue C5F B 504 |
| Chain | Residue |
| B | PHE273 |
| B | CYS276 |
| B | GLN277 |
| B | SER280 |
| B | TYR314 |
| B | PHE318 |
| B | HIS440 |
| B | ILE447 |
| B | ALA455 |
| B | TYR464 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide GW9 B 501 and CYS B 276 |
| Chain | Residue |
| A | PHE421 |
| B | ILE241 |
| B | ILE272 |
| B | HIS274 |
| B | CYS275 |
| B | GLN277 |
| B | CYS278 |
| B | THR279 |
| B | SER280 |
| B | LEU321 |
| B | VAL332 |
| B | GW9502 |
| B | C5F504 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide GW9 B 502 and CYS B 275 |
| Chain | Residue |
| A | PHE421 |
| B | ALA250 |
| B | GLU251 |
| B | LEU254 |
| B | ARG271 |
| B | ILE272 |
| B | PHE273 |
| B | HIS274 |
| B | CYS276 |
| B | GLN277 |
| B | CYS278 |
| B | THR279 |
| B | ALA333 |
| B | TYR334 |
| B | GW9501 |
| B | GW9503 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide GW9 B 503 and CYS B 278 |
| Chain | Residue |
| B | LEU254 |
| B | LYS257 |
| B | LEU258 |
| B | ASN261 |
| B | HIS274 |
| B | CYS275 |
| B | CYS276 |
| B | GLN277 |
| B | THR279 |
| B | SER280 |
| B | VAL281 |
| B | GLU282 |
| B | ALA455 |
| B | LEU456 |
| B | HIS457 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 454 |
| Details | Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 258 |
| Details | Region: {"description":"Required for heterodimerization with RXRA"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19116277","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ET1","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Essential for heterodimerization with RXRA"} |
