6KZD
Crystal structure of TRKc in complex with 3-((6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl)ethynyl)- N-(3-isopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-2- methylbenzamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | NT-3 growth factor receptor | polymer | 312 | 35826.6 | 1 | UniProt (Q16288) Pfam (PF07714) In PDB | Homo sapiens (Human) | GP145-TrkC,Trk-C,Neurotrophic tyrosine kinase receptor type 3,TrkC tyrosine kinase |
| 2 | A | 3-[2-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]ethynyl]-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-propan-2-yl-phenyl]benzamide | non-polymer | 583.7 | 1 | Chemie (DZ6) | |||
| 3 | A | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | water | water | 18.0 | 300 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35826.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 678.7 | |
| All* | Total formula weight | 36505.3 |
