Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue DZ6 A 901 |
| Chain | Residue |
| A | ALA570 |
| A | MET620 |
| A | GLY623 |
| A | HIS677 |
| A | LEU686 |
| A | GLY696 |
| A | ASP697 |
| A | PHE698 |
| A | HOH1012 |
| A | HOH1166 |
| A | LYS572 |
| A | GLU588 |
| A | LEU591 |
| A | LEU592 |
| A | LEU595 |
| A | VAL601 |
| A | GLU618 |
| A | TYR619 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 902 |
| Chain | Residue |
| A | HIS532 |
| A | ILE533 |
| A | LYS534 |
| A | ARG535 |
| A | CYS607 |
| A | GLY608 |
| A | HOH1001 |
| A | HOH1059 |
| A | HOH1064 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVFlAecynlsptkdkml.....VAVK |
| Chain | Residue | Details |
| A | LEU544-LYS572 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV |
| Chain | Residue | Details |
| A | PHE675-VAL687 | |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DVYstdYYR |
| Chain | Residue | Details |
| A | ASP703-ARG711 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interaction with PLC-gamma-1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
