6KZC
crystal structure of TRKc in complex with 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-N-(3-((4- methylpiperazin-1-yl)methyl)-5- (trifluoromethyl)phenyl)benzamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NT-3 growth factor receptor | polymer | 312 | 35826.6 | 1 | UniProt (Q16288) Pfam (PF07714) | Homo sapiens (Human) | GP145-TrkC,Trk-C,Neurotrophic tyrosine kinase receptor type 3,TrkC tyrosine kinase |
| 2 | B (A) | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-~{N}-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide | non-polymer | 518.5 | 1 | Chemie (DZC) | |||
| 3 | C (A) | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35826.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 518.5 | |
| All* | Total formula weight | 36345.1 |
