6KZC

crystal structure of TRKc in complex with 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-N-(3-((4- methylpiperazin-1-yl)methyl)-5- (trifluoromethyl)phenyl)benzamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue DZC A 901

Chain	Residue
A	LEU544
A	PHE617
A	GLU618
A	TYR619
A	MET620
A	HIS677
A	LEU686
A	ILE695
A	GLY696
A	ASP697
A	PHE698
A	ALA570
A	HOH1129
A	LYS572
A	GLU588
A	LEU591
A	LEU592
A	LEU595
A	ILE600
A	VAL601

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVFlAecynlsptkdkml.....VAVK

Chain	Residue	Details
A	LEU544-LYS572

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV

Chain	Residue	Details
A	PHE675-VAL687

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site_id	PS00239
Number of Residues	9
Details	RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DVYstdYYR

Chain	Residue	Details
A	ASP703-ARG711

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP679

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU544
A	LYS572

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Interaction with PLC-gamma-1 => ECO:0000250

Chain	Residue	Details
A	TYR834

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site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250

Chain	Residue	Details
A	TYR705
A	TYR709
A	TYR710

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