6KXS

Cryo-EM structure of human IgM-Fc in complex with the J chain and the ectodomain of pIgR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Immunoglobulin heavy constant mu	polymer	383	41875.8	10	UniProt (P01871) Pfam (PF07654) In PDB	Homo sapiens (Human)	Ig mu chain C region,Ig mu chain C region BOT,Ig mu chain C region GAL,Ig mu chain C region OU
2	J	Immunoglobulin J chain	polymer	136	15483.3	1	UniProt (P01591) Pfam (PF15097) In PDB	Homo sapiens (Human)	Joining chain of multimeric IgA and IgM
3	P	Polymeric immunoglobulin receptor	polymer	555	61371.9	1	UniProt (P01833) Pfam (PF07686) In PDB	Homo sapiens (Human)	Poly-Ig receptor,Hepatocellular carcinoma-associated protein TB6
4	I	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	A, B, C, D, E...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	10	Chemie (NAG)

Sequence modifications

A, B, C, D, E, F, G, H, K, L: 229 - 576 (UniProt: P01871)

PDB	External Database	Details
Ala 194	-	expression tag
Ser 195	-	expression tag
Ala 196	-	expression tag
Trp 197	-	expression tag
Ser 198	-	expression tag
His 199	-	expression tag
Pro 200	-	expression tag
Gln 201	-	expression tag
Phe 202	-	expression tag
Glu 203	-	expression tag
Lys 204	-	expression tag
Gly 205	-	expression tag
Gly 206	-	expression tag
Gly 207	-	expression tag
Ser 208	-	expression tag
Gly 209	-	expression tag
Gly 210	-	expression tag
Gly 211	-	expression tag
Ser 212	-	expression tag
Gly 213	-	expression tag
Gly 214	-	expression tag
Ser 215	-	expression tag
Ala 216	-	expression tag
Trp 217	-	expression tag
Ser 218	-	expression tag
His 219	-	expression tag
Pro 220	-	expression tag
Gln 221	-	expression tag
Phe 222	-	expression tag
Glu 223	-	expression tag
Lys 224	-	expression tag
Ile 225	-	expression tag
Asp 226	-	expression tag
Thr 227	-	expression tag
Thr 228	-	expression tag

P: 1 - 547 (UniProt: P01833)

PDB	External Database	Details
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
His 553	-	expression tag
His 554	-	expression tag
His 555	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	495612.9
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	10
	Total formula weight	2212.1
All*	Total formula weight	498249.3

*Water molecules are not included.