6KXS
Cryo-EM structure of human IgM-Fc in complex with the J chain and the ectodomain of pIgR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| J | 0002250 | biological_process | adaptive immune response |
| J | 0003094 | biological_process | glomerular filtration |
| J | 0003697 | molecular_function | single-stranded DNA binding |
| J | 0003823 | molecular_function | antigen binding |
| J | 0005576 | cellular_component | extracellular region |
| J | 0005615 | cellular_component | extracellular space |
| J | 0006955 | biological_process | immune response |
| J | 0006959 | biological_process | humoral immune response |
| J | 0019731 | biological_process | antibacterial humoral response |
| J | 0019862 | molecular_function | IgA binding |
| J | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| J | 0031210 | molecular_function | phosphatidylcholine binding |
| J | 0034987 | molecular_function | immunoglobulin receptor binding |
| J | 0042803 | molecular_function | protein homodimerization activity |
| J | 0042834 | molecular_function | peptidoglycan binding |
| J | 0045087 | biological_process | innate immune response |
| J | 0060267 | biological_process | positive regulation of respiratory burst |
| J | 0065003 | biological_process | protein-containing complex assembly |
| J | 0070062 | cellular_component | extracellular exosome |
| J | 0071748 | cellular_component | monomeric IgA immunoglobulin complex |
| J | 0071750 | cellular_component | dimeric IgA immunoglobulin complex |
| J | 0071751 | cellular_component | secretory IgA immunoglobulin complex |
| J | 0071752 | cellular_component | secretory dimeric IgA immunoglobulin complex |
| J | 0071756 | cellular_component | pentameric IgM immunoglobulin complex |
| J | 0071757 | cellular_component | hexameric IgM immunoglobulin complex |
| J | 0072562 | cellular_component | blood microparticle |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FTCRVDH |
| Chain | Residue | Details |
| A | PHE318-HIS324 | |
| A | PHE424-HIS430 | |
| A | TYR534-HIS540 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:6526384 |
| Chain | Residue | Details |
| P | ASN65 | |
| L | ASN332 | |
| B | ASN332 | |
| C | ASN332 | |
| D | ASN332 | |
| E | ASN332 | |
| F | ASN332 | |
| G | ASN332 | |
| H | ASN332 | |
| K | ASN332 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:6526384 |
| Chain | Residue | Details |
| P | ASN72 | |
| L | ASN395 | |
| B | ASN395 | |
| C | ASN395 | |
| D | ASN395 | |
| E | ASN395 | |
| F | ASN395 | |
| G | ASN395 | |
| H | ASN395 | |
| K | ASN395 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:6526384 |
| Chain | Residue | Details |
| P | ASN117 | |
| L | ASN402 | |
| B | ASN402 | |
| C | ASN402 | |
| D | ASN402 | |
| E | ASN402 | |
| F | ASN402 | |
| G | ASN402 | |
| H | ASN402 | |
| K | ASN402 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:6526384 |
| Chain | Residue | Details |
| P | ASN168 | |
| P | ASN481 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6526384 |
| Chain | Residue | Details |
| P | ASN403 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6526384 |
| Chain | Residue | Details |
| P | ASN451 |
