6KTO

Crystal structure of human SHLD3-C-REV7-O-REV7-SHLD2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Mitotic spindle assembly checkpoint protein MAD2B	polymer	227	26187.4	2	UniProt (Q9UI95) Pfam (PF02301) In PDB	Homo sapiens (Human)	Mitotic arrest deficient 2-like protein 2,MAD2-like protein 2,REV7 homolog,hREV7
2	C	Shieldin complex subunit 3	polymer	64	7402.5	1	UniProt (Q6ZNX1) In PDB	Homo sapiens (Human)	REV7-interacting novel NHEJ regulator 1,Shield complex subunit 3
3	D	Shieldin complex subunit 2	polymer	54	5953.9	1	UniProt (Q86V20) In PDB	Homo sapiens (Human)	Protein FAM35A,RINN1-REV7-interacting novel NHEJ regulator 2,Shield complex subunit 2

Sequence modifications

A, B: 1 - 211 (UniProt: Q9UI95)

PDB	External Database	Details
Met -15	-	expression tag
Gly -14	-	expression tag
Ser -13	-	expression tag
Ser -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
Ser -5	-	expression tag
Gln -4	-	expression tag
Asp -3	-	expression tag
Pro -2	-	expression tag
Asn -1	-	expression tag
Ser 0	-	expression tag

D: 1 - 52 (UniProt: Q86V20)

PDB	External Database	Details
Met -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	65731.2
All*	Total formula weight	65731.2

*Water molecules are not included.