6KP6

The structural study of mutation induced inactivation of Human muscarinic receptor M4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Muscarinic acetylcholine receptor M4,GlgA glycogen synthase,Muscarinic acetylcholine receptor M4	polymer	492	55439.8	1	UniProt (P08173) UniProt (Q9V2J8) Pfam (PF00001) Pfam (PF13692) In PDB	Homo sapiens (Human)	Glycogen synthase

Sequence modifications

A: 22 - 227 (UniProt: P08173)

PDB	External Database	Details
Thr 93	Ile 93	engineered mutation
Ala 150	Gly 150	engineered mutation
Ala 187	Ile 187	engineered mutation
Tyr 219	Ser 219	engineered mutation

A: 1001 - 1196 (UniProt: Q9V2J8)
A: 390 - 479 (UniProt: P08173)

PDB	External Database	Details
Arg 449	Asn 449	engineered mutation
Glu 459	Thr 459	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	55439.8
All*	Total formula weight	55439.8

*Water molecules are not included.