6KMZ
caspase-4 P22/P10 C258A in complex with human GSDMD-C domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, D, E (A, B, C, D) | Caspase-4 | polymer | 185 | 20987.7 | 4 | UniProt (P49662) Pfam (PF00656) | Homo sapiens (Human) | CASP-4,ICE and Ced-3 homolog 2,ICH-2,ICE(rel)-II,Mih1,Protease TX |
| 2 | C (E) | Gasdermin-D | polymer | 194 | 20757.8 | 1 | UniProt (P57764) Pfam (PF17708) | Homo sapiens (Human) | Gasdermin domain-containing protein 1 |
| 3 | F (H) | Gasdermin-D | polymer | 195 | 20872.9 | 1 | UniProt (P57764) Pfam (PF17708) | Homo sapiens (Human) | Gasdermin domain-containing protein 1 |
| 4 | G, H, I, J (a, b, c, d) | Caspase-4 | polymer | 88 | 10424.0 | 4 | UniProt (P49662) Pfam (PF00656) | Homo sapiens (Human) | CASP-4,ICE and Ced-3 homolog 2,ICH-2,ICE(rel)-II,Mih1,Protease TX |
Sequence modifications
A, B, C, D: 105 - 285 (UniProt: P49662)
| PDB | External Database | Details |
|---|---|---|
| Ala 258 | Cys 258 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 167277.6 | |
| All* | Total formula weight | 167277.6 |
