6KMZ
caspase-4 P22/P10 C258A in complex with human GSDMD-C domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| a | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| a | 0006508 | biological_process | proteolysis |
| a | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| b | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| b | 0006508 | biological_process | proteolysis |
| b | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| c | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| c | 0006508 | biological_process | proteolysis |
| c | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| d | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| d | 0006508 | biological_process | proteolysis |
| d | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PROSITE/UniProt
| site_id | PS01121 |
| Number of Residues | 15 |
| Details | CASPASE_HIS Caspase family histidine active site. HkssdStfLvLMSHG |
| Chain | Residue | Details |
| A | HIS197-GLY211 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"P29466","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"22246630","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23661706","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25119034","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37993712","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37993714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7743998","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by papain","evidences":[{"source":"PubMed","id":"35794369","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"S-(2-succinyl)cysteine","evidences":[{"source":"PubMed","id":"32820063","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"PubMed","id":"37962578","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"(Microbial infection) ADP-riboxanated arginine","evidences":[{"source":"PubMed","id":"34671164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36624349","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
