6KMV

caspase-11 C254A P22/P10 in complex with mouse GSDMD-C domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Caspase-4	polymer	161	18030.6	1	UniProt (P70343) Pfam (PF00656) In PDB	Mus musculus (Mouse)	CASP-4,Caspase-11,CASP-11,Protease ICH-3
2	B, V	Caspase-4	polymer	167	18870.6	2	UniProt (P70343) Pfam (PF00656) In PDB	Mus musculus (Mouse)	CASP-4,Caspase-11,CASP-11,Protease ICH-3
3	C, G, O	Gasdermin-D	polymer	198	21497.5	3	UniProt (Q9D8T2) Pfam (PF17708) In PDB	Mus musculus (Mouse)	Gasdermin domain-containing protein 1
4	D, K, S, T, W...	Gasdermin-D	polymer	197	21426.4	7	UniProt (Q9D8T2) Pfam (PF17708) In PDB	Mus musculus (Mouse)	Gasdermin domain-containing protein 1
5	E, F, Z, d	Caspase-4	polymer	166	18783.5	4	UniProt (P70343) Pfam (PF00656) In PDB	Mus musculus (Mouse)	CASP-4,Caspase-11,CASP-11,Protease ICH-3
6	H	Gasdermin-D	polymer	191	20702.7	1	UniProt (Q9D8T2) Pfam (PF17708) In PDB	Mus musculus (Mouse)	Gasdermin domain-containing protein 1
7	I, M, N, Q, Y	Caspase-4	polymer	165	18682.4	5	UniProt (P70343) Pfam (PF00656) In PDB	Mus musculus (Mouse)	CASP-4,Caspase-11,CASP-11,Protease ICH-3
8	J	Caspase-4	polymer	149	16744.1	1	UniProt (P70343) Pfam (PF00656) In PDB	Mus musculus (Mouse)	CASP-4,Caspase-11,CASP-11,Protease ICH-3
9	L, P, e	Gasdermin-D	polymer	214	23225.4	3	UniProt (Q9D8T2) Pfam (PF17708) In PDB	Mus musculus (Mouse)	Gasdermin domain-containing protein 1
10	R, c	Caspase-4	polymer	150	16831.2	2	UniProt (P70343) Pfam (PF00656) In PDB	Mus musculus (Mouse)	CASP-4,Caspase-11,CASP-11,Protease ICH-3
11	U	Caspase-4	polymer	165	18654.4	1	UniProt (P70343) Pfam (PF00656) In PDB	Mus musculus (Mouse)	CASP-4,Caspase-11,CASP-11,Protease ICH-3
12	X	Gasdermin-D	polymer	199	21568.6	1	UniProt (Q9D8T2) Pfam (PF17708) In PDB	Mus musculus (Mouse)	Gasdermin domain-containing protein 1
13	a	Gasdermin-D	polymer	196	21311.3	1	UniProt (Q9D8T2) Pfam (PF17708) In PDB	Mus musculus (Mouse)	Gasdermin domain-containing protein 1
14	g, h, i, j, k...	Caspase-4	polymer	88	10283.8	15	UniProt (P70343) Pfam (PF00656) In PDB	Mus musculus (Mouse)	CASP-4,Caspase-11,CASP-11,Protease ICH-3
15	s	Caspase-4	polymer	87	10212.8	1	UniProt (P70343) Pfam (PF00656) In PDB	Mus musculus (Mouse)	CASP-4,Caspase-11,CASP-11,Protease ICH-3

Sequence modifications

A: 118 - 278 (UniProt: P70343)

PDB	External Database	Details
Ala 254	Cys 254	engineered mutation

B, V: 101 - 267 (UniProt: P70343)

PDB	External Database	Details
Ala 254	Cys 254	engineered mutation

E, F, Z, d: 101 - 266 (UniProt: P70343)

PDB	External Database	Details
Ala 254	Cys 254	engineered mutation

I, M, N, Q, Y: 102 - 266 (UniProt: P70343)

PDB	External Database	Details
Ala 254	Cys 254	engineered mutation

J: 118 - 266 (UniProt: P70343)

PDB	External Database	Details
Ala 254	Cys 254	engineered mutation

R, c: 118 - 267 (UniProt: P70343)

PDB	External Database	Details
Ala 254	Cys 254	engineered mutation

U: 101 - 265 (UniProt: P70343)

PDB	External Database	Details
Ala 254	Cys 254	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	48
	Total formula weight	805585.2
All*	Total formula weight	805585.2

*Water molecules are not included.