Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6KMV

caspase-11 C254A P22/P10 in complex with mouse GSDMD-C domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
E	0004197	molecular_function	cysteine-type endopeptidase activity
E	0006508	biological_process	proteolysis
E	0008234	molecular_function	cysteine-type peptidase activity
F	0004197	molecular_function	cysteine-type endopeptidase activity
F	0006508	biological_process	proteolysis
F	0008234	molecular_function	cysteine-type peptidase activity
I	0004197	molecular_function	cysteine-type endopeptidase activity
I	0006508	biological_process	proteolysis
I	0008234	molecular_function	cysteine-type peptidase activity
J	0004197	molecular_function	cysteine-type endopeptidase activity
J	0006508	biological_process	proteolysis
J	0008234	molecular_function	cysteine-type peptidase activity
M	0004197	molecular_function	cysteine-type endopeptidase activity
M	0006508	biological_process	proteolysis
M	0008234	molecular_function	cysteine-type peptidase activity
N	0004197	molecular_function	cysteine-type endopeptidase activity
N	0006508	biological_process	proteolysis
N	0008234	molecular_function	cysteine-type peptidase activity
Q	0004197	molecular_function	cysteine-type endopeptidase activity
Q	0006508	biological_process	proteolysis
Q	0008234	molecular_function	cysteine-type peptidase activity
R	0004197	molecular_function	cysteine-type endopeptidase activity
R	0006508	biological_process	proteolysis
R	0008234	molecular_function	cysteine-type peptidase activity
U	0004197	molecular_function	cysteine-type endopeptidase activity
U	0006508	biological_process	proteolysis
U	0008234	molecular_function	cysteine-type peptidase activity
V	0004197	molecular_function	cysteine-type endopeptidase activity
V	0006508	biological_process	proteolysis
V	0008234	molecular_function	cysteine-type peptidase activity
Y	0004197	molecular_function	cysteine-type endopeptidase activity
Y	0006508	biological_process	proteolysis
Y	0008234	molecular_function	cysteine-type peptidase activity
Z	0004197	molecular_function	cysteine-type endopeptidase activity
Z	0006508	biological_process	proteolysis
Z	0008234	molecular_function	cysteine-type peptidase activity
c	0004197	molecular_function	cysteine-type endopeptidase activity
c	0006508	biological_process	proteolysis
c	0008234	molecular_function	cysteine-type peptidase activity
d	0004197	molecular_function	cysteine-type endopeptidase activity
d	0006508	biological_process	proteolysis
d	0008234	molecular_function	cysteine-type peptidase activity
g	0004197	molecular_function	cysteine-type endopeptidase activity
g	0006508	biological_process	proteolysis
g	0008234	molecular_function	cysteine-type peptidase activity
h	0004197	molecular_function	cysteine-type endopeptidase activity
h	0006508	biological_process	proteolysis
h	0008234	molecular_function	cysteine-type peptidase activity
i	0004197	molecular_function	cysteine-type endopeptidase activity
i	0006508	biological_process	proteolysis
i	0008234	molecular_function	cysteine-type peptidase activity
j	0004197	molecular_function	cysteine-type endopeptidase activity
j	0006508	biological_process	proteolysis
j	0008234	molecular_function	cysteine-type peptidase activity
k	0004197	molecular_function	cysteine-type endopeptidase activity
k	0006508	biological_process	proteolysis
k	0008234	molecular_function	cysteine-type peptidase activity
l	0004197	molecular_function	cysteine-type endopeptidase activity
l	0006508	biological_process	proteolysis
l	0008234	molecular_function	cysteine-type peptidase activity
m	0004197	molecular_function	cysteine-type endopeptidase activity
m	0006508	biological_process	proteolysis
m	0008234	molecular_function	cysteine-type peptidase activity
n	0004197	molecular_function	cysteine-type endopeptidase activity
n	0006508	biological_process	proteolysis
n	0008234	molecular_function	cysteine-type peptidase activity
o	0004197	molecular_function	cysteine-type endopeptidase activity
o	0006508	biological_process	proteolysis
o	0008234	molecular_function	cysteine-type peptidase activity
p	0004197	molecular_function	cysteine-type endopeptidase activity
p	0006508	biological_process	proteolysis
p	0008234	molecular_function	cysteine-type peptidase activity
q	0004197	molecular_function	cysteine-type endopeptidase activity
q	0006508	biological_process	proteolysis
q	0008234	molecular_function	cysteine-type peptidase activity
r	0004197	molecular_function	cysteine-type endopeptidase activity
r	0006508	biological_process	proteolysis
r	0008234	molecular_function	cysteine-type peptidase activity
s	0004197	molecular_function	cysteine-type endopeptidase activity
s	0006508	biological_process	proteolysis
s	0008234	molecular_function	cysteine-type peptidase activity
t	0004197	molecular_function	cysteine-type endopeptidase activity
t	0006508	biological_process	proteolysis
t	0008234	molecular_function	cysteine-type peptidase activity
u	0004197	molecular_function	cysteine-type endopeptidase activity
u	0006508	biological_process	proteolysis
u	0008234	molecular_function	cysteine-type peptidase activity
v	0004197	molecular_function	cysteine-type endopeptidase activity
v	0006508	biological_process	proteolysis
v	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PROSITE/UniProt

site_id	PS01121
Number of Residues	15
Details	CASPASE_HIS Caspase family histidine active site. HqtsdStfLvLMSHG

Chain	Residue	Details
A	HIS193-GLY207
U	HIS193-GLY207
c	HIS193-GLY207
d	HIS193-GLY207
I	HIS193-GLY207
J	HIS193-GLY207
B	HIS193-GLY207

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: (Microbial infection) ADP-riboxanated arginine => ECO:0000269\|PubMed:34671164

Chain	Residue	Details
v	ARG310
m	ARG310
n	ARG310
o	ARG310
p	ARG310
q	ARG310
r	ARG310
t	ARG310
u	ARG310
s	ARG310
h	ARG310
i	ARG310
j	ARG310
k	ARG310
l	ARG310

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: S-(2-succinyl)cysteine => ECO:0000269\|PubMed:32820063

Chain	Residue	Details
Q	ALA254
T	CYS299
T	CYS434
W	CYS299
W	CYS434
b	CYS299
b	CYS434
f	CYS299
f	CYS434
e	LEU310
Y	ALA254
S	CYS434
a	CYS299
a	CYS434

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: S-(2-succinyl)cysteine => ECO:0000269\|PubMed:32820063

Chain	Residue	Details
L	CYS299
L	CYS434
P	CYS299
P	CYS434
e	CYS299
e	CYS434

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)