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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6KMV

caspase-11 C254A P22/P10 in complex with mouse GSDMD-C domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0004197molecular_functioncysteine-type endopeptidase activity
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
B0004197molecular_functioncysteine-type endopeptidase activity
B0006508biological_processproteolysis
B0008234molecular_functioncysteine-type peptidase activity
E0004197molecular_functioncysteine-type endopeptidase activity
E0006508biological_processproteolysis
E0008234molecular_functioncysteine-type peptidase activity
F0004197molecular_functioncysteine-type endopeptidase activity
F0006508biological_processproteolysis
F0008234molecular_functioncysteine-type peptidase activity
I0004197molecular_functioncysteine-type endopeptidase activity
I0006508biological_processproteolysis
I0008234molecular_functioncysteine-type peptidase activity
J0004197molecular_functioncysteine-type endopeptidase activity
J0006508biological_processproteolysis
J0008234molecular_functioncysteine-type peptidase activity
M0004197molecular_functioncysteine-type endopeptidase activity
M0006508biological_processproteolysis
M0008234molecular_functioncysteine-type peptidase activity
N0004197molecular_functioncysteine-type endopeptidase activity
N0006508biological_processproteolysis
N0008234molecular_functioncysteine-type peptidase activity
Q0004197molecular_functioncysteine-type endopeptidase activity
Q0006508biological_processproteolysis
Q0008234molecular_functioncysteine-type peptidase activity
R0004197molecular_functioncysteine-type endopeptidase activity
R0006508biological_processproteolysis
R0008234molecular_functioncysteine-type peptidase activity
U0004197molecular_functioncysteine-type endopeptidase activity
U0006508biological_processproteolysis
U0008234molecular_functioncysteine-type peptidase activity
V0004197molecular_functioncysteine-type endopeptidase activity
V0006508biological_processproteolysis
V0008234molecular_functioncysteine-type peptidase activity
Y0004197molecular_functioncysteine-type endopeptidase activity
Y0006508biological_processproteolysis
Y0008234molecular_functioncysteine-type peptidase activity
Z0004197molecular_functioncysteine-type endopeptidase activity
Z0006508biological_processproteolysis
Z0008234molecular_functioncysteine-type peptidase activity
c0004197molecular_functioncysteine-type endopeptidase activity
c0006508biological_processproteolysis
c0008234molecular_functioncysteine-type peptidase activity
d0004197molecular_functioncysteine-type endopeptidase activity
d0006508biological_processproteolysis
d0008234molecular_functioncysteine-type peptidase activity
g0004197molecular_functioncysteine-type endopeptidase activity
g0006508biological_processproteolysis
g0008234molecular_functioncysteine-type peptidase activity
h0004197molecular_functioncysteine-type endopeptidase activity
h0006508biological_processproteolysis
h0008234molecular_functioncysteine-type peptidase activity
i0004197molecular_functioncysteine-type endopeptidase activity
i0006508biological_processproteolysis
i0008234molecular_functioncysteine-type peptidase activity
j0004197molecular_functioncysteine-type endopeptidase activity
j0006508biological_processproteolysis
j0008234molecular_functioncysteine-type peptidase activity
k0004197molecular_functioncysteine-type endopeptidase activity
k0006508biological_processproteolysis
k0008234molecular_functioncysteine-type peptidase activity
l0004197molecular_functioncysteine-type endopeptidase activity
l0006508biological_processproteolysis
l0008234molecular_functioncysteine-type peptidase activity
m0004197molecular_functioncysteine-type endopeptidase activity
m0006508biological_processproteolysis
m0008234molecular_functioncysteine-type peptidase activity
n0004197molecular_functioncysteine-type endopeptidase activity
n0006508biological_processproteolysis
n0008234molecular_functioncysteine-type peptidase activity
o0004197molecular_functioncysteine-type endopeptidase activity
o0006508biological_processproteolysis
o0008234molecular_functioncysteine-type peptidase activity
p0004197molecular_functioncysteine-type endopeptidase activity
p0006508biological_processproteolysis
p0008234molecular_functioncysteine-type peptidase activity
q0004197molecular_functioncysteine-type endopeptidase activity
q0006508biological_processproteolysis
q0008234molecular_functioncysteine-type peptidase activity
r0004197molecular_functioncysteine-type endopeptidase activity
r0006508biological_processproteolysis
r0008234molecular_functioncysteine-type peptidase activity
s0004197molecular_functioncysteine-type endopeptidase activity
s0006508biological_processproteolysis
s0008234molecular_functioncysteine-type peptidase activity
t0004197molecular_functioncysteine-type endopeptidase activity
t0006508biological_processproteolysis
t0008234molecular_functioncysteine-type peptidase activity
u0004197molecular_functioncysteine-type endopeptidase activity
u0006508biological_processproteolysis
u0008234molecular_functioncysteine-type peptidase activity
v0004197molecular_functioncysteine-type endopeptidase activity
v0006508biological_processproteolysis
v0008234molecular_functioncysteine-type peptidase activity
Functional Information from PROSITE/UniProt
site_idPS01121
Number of Residues15
DetailsCASPASE_HIS Caspase family histidine active site. HqtsdStfLvLMSHG
ChainResidueDetails
JHIS193-GLY207
BHIS193-GLY207
IHIS193-GLY207
dHIS193-GLY207
AHIS193-GLY207
UHIS193-GLY207
cHIS193-GLY207
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsActive site: {"evidences":[{"source":"UniProtKB","id":"P29466","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues16
DetailsActive site: {"evidences":[{"source":"UniProtKB","id":"P49662","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues16
DetailsSite: {"description":"Cleavage; by papain","evidences":[{"source":"PubMed","id":"35794369","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues30
DetailsModified residue: {"description":"S-(2-succinyl)cysteine","evidences":[{"source":"PubMed","id":"32820063","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues60
DetailsRegion: {"description":"Linker helix loop","evidences":[{"source":"UniProtKB","id":"P57764","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsSite: {"description":"Cleavage; by caspases CASP1, CASP4/CASP11 and CASP8","evidences":[{"source":"PubMed","id":"26375259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30361383","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32553275","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38538834","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30135078","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues16
DetailsModified residue: {"description":"(Microbial infection) ADP-riboxanated arginine","evidences":[{"source":"PubMed","id":"34671164","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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