6KKR

human KCC1 structure determined in KCl and detergent GDN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Solute carrier family 12 member 4	polymer	1095	122054.9	2	UniProt (Q9UP95) Pfam (PF00324) Pfam (PF03522)	Homo sapiens (Human)	Electroneutral potassium-chloride cotransporter 1,Erythroid K-Cl cotransporter 1,hKCC1
2	C, D, G, H (C, D, G, H)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
3	E, F, I, J (E, F, I, J)	alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose	branched		342.3	4	In PDB BIRD (PRD_900018) GlyTouCan (G66120GK)		beta-maltose
4	K, M, O, Q (A, B)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
5	L, P (A, B)	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
6	N, R (A, B)	2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol	non-polymer		516.8	2	Chemie (DU0)

Sequence modifications

A, B: 1 - 1085 (UniProt: Q9UP95)

PDB	External Database	Details
Leu 1086	-	expression tag
Glu 1087	-	expression tag
Trp 1088	-	expression tag
Ser 1089	-	expression tag
His 1090	-	expression tag
Pro 1091	-	expression tag
Gln 1092	-	expression tag
Phe 1093	-	expression tag
Glu 1094	-	expression tag
Lys 1095	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	244109.8
Branched	Number of molecules	8
	Total formula weight	3066.8
Non-Polymers*	Number of molecules	8
	Total formula weight	1253.5
All*	Total formula weight	248430.1

*Water molecules are not included.