6KKR
human KCC1 structure determined in KCl and detergent GDN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006884 | biological_process | cell volume homeostasis |
| A | 0007268 | biological_process | chemical synaptic transmission |
| A | 0008519 | molecular_function | ammonium transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| A | 0015379 | molecular_function | potassium:chloride symporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0045202 | cellular_component | synapse |
| A | 0055064 | biological_process | chloride ion homeostasis |
| A | 0055075 | biological_process | potassium ion homeostasis |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 0140157 | biological_process | ammonium import across plasma membrane |
| A | 1902476 | biological_process | chloride transmembrane transport |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006884 | biological_process | cell volume homeostasis |
| B | 0007268 | biological_process | chemical synaptic transmission |
| B | 0008519 | molecular_function | ammonium transmembrane transporter activity |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
| B | 0015379 | molecular_function | potassium:chloride symporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0022857 | molecular_function | transmembrane transporter activity |
| B | 0045202 | cellular_component | synapse |
| B | 0055064 | biological_process | chloride ion homeostasis |
| B | 0055075 | biological_process | potassium ion homeostasis |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0140157 | biological_process | ammonium import across plasma membrane |
| B | 1902476 | biological_process | chloride transmembrane transport |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1236 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR |
| Chain | Residue | Details |
| A | MET1-GLY119 | |
| B | ALA532-PRO554 | |
| B | GLN599-LYS612 | |
| B | ILE652-SER1085 | |
| A | ALA173-GLU196 | |
| A | SER441-SER450 | |
| A | ALA532-PRO554 | |
| A | GLN599-LYS612 | |
| A | ILE652-SER1085 | |
| B | MET1-GLY119 | |
| B | ALA173-GLU196 | |
| B | SER441-SER450 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | TRANSMEM: Discontinuously helical => ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR |
| Chain | Residue | Details |
| A | THR120-LEU141 | |
| B | THR120-LEU141 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 360 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR |
| Chain | Residue | Details |
| A | THR142-GLY149 | |
| A | THR226-LEU248 | |
| A | SER298-SER419 | |
| A | GLY474-PRO504 | |
| B | THR142-GLY149 | |
| B | THR226-LEU248 | |
| B | SER298-SER419 | |
| B | GLY474-PRO504 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 488 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:31649201, ECO:0000269|PubMed:34031912, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR |
| Chain | Residue | Details |
| A | VAL150-SER172 | |
| A | TYR613-TRP635 | |
| A | TYR636-TYR651 | |
| B | VAL150-SER172 | |
| B | PHE197-LEU225 | |
| B | ASN249-LYS271 | |
| B | TYR272-LYS297 | |
| B | PHE420-ARG440 | |
| B | ILE451-PHE473 | |
| B | TRP505-GLN531 | |
| B | THR555-ASP575 | |
| A | PHE197-LEU225 | |
| B | MET576-VAL598 | |
| B | TYR613-TRP635 | |
| B | TYR636-TYR651 | |
| A | ASN249-LYS271 | |
| A | TYR272-LYS297 | |
| A | PHE420-ARG440 | |
| A | ILE451-PHE473 | |
| A | TRP505-GLN531 | |
| A | THR555-ASP575 | |
| A | MET576-VAL598 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31649201, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT |
| Chain | Residue | Details |
| A | ASN131 | |
| A | ILE132 | |
| A | PRO429 | |
| A | THR432 | |
| B | ASN131 | |
| B | ILE132 | |
| B | PRO429 | |
| B | THR432 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:31649201, ECO:0007744|PDB:6KKR |
| Chain | Residue | Details |
| A | TYR216 | |
| B | TYR216 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:31649201 |
| Chain | Residue | Details |
| A | GLY433 | |
| A | ILE434 | |
| A | MET435 | |
| A | TYR589 | |
| B | GLY433 | |
| B | ILE434 | |
| B | MET435 | |
| B | TYR589 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34031912, ECO:0007744|PDB:7AIP |
| Chain | Residue | Details |
| A | LEU697 | |
| A | VAL730 | |
| B | LEU697 | |
| B | VAL730 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34031912, ECO:0007744|PDB:7AIP, ECO:0007744|PDB:7AIQ |
| Chain | Residue | Details |
| A | LYS699 | |
| A | TYR708 | |
| B | LYS699 | |
| B | TYR708 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34031912, ECO:0007744|PDB:7AIR |
| Chain | Residue | Details |
| A | LYS707 | |
| A | TRP795 | |
| A | TYR797 | |
| B | LYS707 | |
| B | TRP795 | |
| B | TYR797 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:34031912, ECO:0007744|PDB:7AIQ, ECO:0007744|PDB:7AIR |
| Chain | Residue | Details |
| A | GLY794 | |
| B | GLY794 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER24 | |
| B | SER24 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JIS8 |
| Chain | Residue | Details |
| A | SER47 | |
| B | SER47 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER51 | |
| B | SER51 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9UHW9 |
| Chain | Residue | Details |
| A | SER81 | |
| B | SER81 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER88 | |
| B | SER88 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:34031912 |
| Chain | Residue | Details |
| A | SER734 | |
| A | SER1050 | |
| B | SER734 | |
| B | SER1050 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER967 | |
| B | SER967 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR983 | |
| B | THR983 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN245 | |
| A | ASN331 | |
| A | ASN347 | |
| B | ASN245 | |
| B | ASN331 | |
| B | ASN347 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31649201, ECO:0007744|PDB:6KKR, ECO:0007744|PDB:6KKT, ECO:0007744|PDB:6KKU |
| Chain | Residue | Details |
| A | ASN312 | |
| B | ASN312 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31649201 |
| Chain | Residue | Details |
| A | ASN361 | |
| B | ASN361 |
