6KK7

Structure of thermal-stabilised(M6) human GLP-1 receptor transmembrane domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Glucagon-like peptide 1 receptor,Endolysin,Glucagon-like peptide 1 receptor	polymer	455	52549.2	2	UniProt (P43220) UniProt (P00720) Pfam (PF00002) Pfam (PF00959)	Homo sapiens (Human)	GLP-1R,Lysis protein,Lysozyme,Muramidase,GLP-1R
2	C, D (A, B)	N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine	non-polymer		515.5	2	Chemie (97Y)

Sequence modifications

A, B: 128 - 257 (UniProt: P43220)

PDB	External Database	Details
Ser 127	-	expression tag
-	Tyr 205	deletion
-	Ser 206	deletion
-	Thr 207	deletion
-	Ala 208	deletion
-	Ala 209	deletion
-	Gln 210	deletion
-	Gln 211	deletion
-	His 212	deletion
-	Gln 213	deletion
-	Trp 214	deletion
Gly 212	-	linker
Ser 213	-	linker
Gly 214	-	linker
Ala 225	Ser 225	engineered mutation

A, B: 1001 - 1160 (UniProt: P00720)

PDB	External Database	Details
Gly 1011	Arg 12	engineered mutation
Thr 1053	Cys 54	engineered mutation
Ala 1096	Cys 97	engineered mutation
Arg 1136	Ile 137	engineered mutation

A, B: 261 - 431 (UniProt: P43220)

PDB	External Database	Details
Cys 317	Ile 317	engineered mutation
Ile 318	Gly 318	engineered mutation
Ala 346	Lys 346	engineered mutation
Phe 347	Cys 347	engineered mutation
Cys 361	Gly 361	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	105098.5
Non-Polymers*	Number of molecules	2
	Total formula weight	1031.1
All*	Total formula weight	106129.5

*Water molecules are not included.