6KK7
Structure of thermal-stabilised(M6) human GLP-1 receptor transmembrane domain
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003796 | molecular_function | lysozyme activity |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0004930 | molecular_function | G protein-coupled receptor activity |
A | 0007166 | biological_process | cell surface receptor signaling pathway |
A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
A | 0009253 | biological_process | peptidoglycan catabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
A | 0016998 | biological_process | cell wall macromolecule catabolic process |
A | 0030430 | cellular_component | host cell cytoplasm |
A | 0031640 | biological_process | killing of cells of another organism |
A | 0042742 | biological_process | defense response to bacterium |
A | 0044659 | biological_process | viral release from host cell by cytolysis |
B | 0003796 | molecular_function | lysozyme activity |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0004930 | molecular_function | G protein-coupled receptor activity |
B | 0007166 | biological_process | cell surface receptor signaling pathway |
B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
B | 0009253 | biological_process | peptidoglycan catabolic process |
B | 0016020 | cellular_component | membrane |
B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
B | 0016998 | biological_process | cell wall macromolecule catabolic process |
B | 0030430 | cellular_component | host cell cytoplasm |
B | 0031640 | biological_process | killing of cells of another organism |
B | 0042742 | biological_process | defense response to bacterium |
B | 0044659 | biological_process | viral release from host cell by cytolysis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue 97Y A 2001 |
Chain | Residue |
A | ILE328 |
A | ARG348 |
A | LYS351 |
A | THR355 |
A | LEU401 |
A | VAL405 |
A | ASN406 |
A | ASN407 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue 97Y B 2001 |
Chain | Residue |
B | LEU335 |
B | PHE347 |
B | ARG348 |
B | LYS351 |
B | SER352 |
B | VAL405 |
B | ASN406 |
A | ILE286 |
Functional Information from PROSITE/UniProt
site_id | PS00650 |
Number of Residues | 16 |
Details | G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLMVaILYCFvNneV |
Chain | Residue | Details |
A | GLN394-VAL409 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:28514449 |
Chain | Residue | Details |
A | GLN140-ALA164 | |
B | GLN140-ALA164 |
site_id | SWS_FT_FI2 |
Number of Residues | 58 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:28514449 |
Chain | Residue | Details |
A | ILE165-THR175 | |
A | CYS329-ARG348 | |
B | ILE165-THR175 | |
B | CYS329-ARG348 |
site_id | SWS_FT_FI3 |
Number of Residues | 50 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:28514449 |
Chain | Residue | Details |
A | ARG176-LEU201 | |
B | ARG176-LEU201 |
site_id | SWS_FT_FI4 |
Number of Residues | 102 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:28514449 |
Chain | Residue | Details |
A | LYS202-GLN234 | |
A | TYR291-TYR305 | |
A | MET371-LYS383 | |
B | LYS202-GLN234 | |
B | TYR291-TYR305 | |
B | MET371-LYS383 |
site_id | SWS_FT_FI5 |
Number of Residues | 46 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:28514449 |
Chain | Residue | Details |
A | LEU228-LEU251 | |
B | LEU228-LEU251 |
site_id | SWS_FT_FI6 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:28514449 |
Chain | Residue | Details |
A | PHE266-LEU290 | |
B | PHE266-LEU290 |
site_id | SWS_FT_FI7 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:28514449 |
Chain | Residue | Details |
A | TRP306-ILE328 | |
B | TRP306-ILE328 |
site_id | SWS_FT_FI8 |
Number of Residues | 42 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:28514449 |
Chain | Residue | Details |
A | LEU349-VAL370 | |
B | LEU349-VAL370 |
site_id | SWS_FT_FI9 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:28514449 |
Chain | Residue | Details |
A | LEU384-PHE404 | |
B | LEU384-PHE404 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | SITE: Interaction with the endogenous ligand GLP-1 => ECO:0000269|PubMed:19861722 |
Chain | Residue | Details |
A | GLU128 | |
B | GLU128 |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | MOD_RES: ADP-ribosylcysteine => ECO:0000269|PubMed:21901419 |
Chain | Residue | Details |
A | CYS341 | |
B | CYS341 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | MOD_RES: ADP-ribosylarginine => ECO:0000269|PubMed:21901419 |
Chain | Residue | Details |
A | ARG348 | |
B | ARG348 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
Chain | Residue | Details |
A | GLU1010 | |
B | GLU1010 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
Chain | Residue | Details |
A | ASP1019 | |
B | ASP1019 |
site_id | SWS_FT_FI15 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8266098 |
Chain | Residue | Details |
A | LEU1031 | |
A | PHE1103 | |
B | LEU1031 | |
B | PHE1103 |
site_id | SWS_FT_FI16 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000303|PubMed:7831309 |
Chain | Residue | Details |
A | SER1116 | |
A | ASN1131 | |
B | SER1116 | |
B | ASN1131 |