6KDY
Crystal structure of the alpha bata heterodimer of human IDH3 in complex with NAD.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | polymer | 341 | 36826.3 | 4 | UniProt (P50213) Pfam (PF00180) In PDB | Homo sapiens (Human) | Isocitric dehydrogenase subunit alpha,NAD(+)-specific ICDH subunit alpha |
2 | B, D, F, H | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | polymer | 356 | 39703.7 | 4 | UniProt (O43837) Pfam (PF00180) In PDB | Homo sapiens (Human) | Isocitric dehydrogenase subunit beta,NAD(+)-specific ICDH subunit beta |
3 | A, C, E, G | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 4 | Chemie (NAD) | |||
4 | B, D | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
5 | D | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 1 | Chemie (2PE) | |||
6 | F | 1-DEOXY-1-THIO-HEPTAETHYLENE GLYCOL | non-polymer | 342.4 | 1 | Chemie (PE7) | |||
7 | H | HEXAETHYLENE GLYCOL | non-polymer | 282.3 | 1 | Chemie (P6G) |
Sequence modifications
A, C, E, G: 1 - 339 (UniProt: P50213)
B, D, F, H: 1 - 340 (UniProt: O43837)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Glu 341 | - | expression tag |
Ile 342 | - | expression tag |
Cys 343 | - | expression tag |
Arg 344 | - | expression tag |
Arg 345 | - | expression tag |
Val 346 | - | expression tag |
Lys 347 | - | expression tag |
Asp 348 | - | expression tag |
Leu 349 | - | expression tag |
Asp 350 | - | expression tag |
Glu 351 | - | expression tag |
Asn 352 | - | expression tag |
Leu 353 | - | expression tag |
Tyr 354 | - | expression tag |
Phe 355 | - | expression tag |
Gln 356 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 306119.9 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 4081.4 | |
All* | Total formula weight | 310201.3 |