6KDY

Crystal structure of the alpha bata heterodimer of human IDH3 in complex with NAD.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005975	biological_process	carbohydrate metabolic process
A	0006099	biological_process	tricarboxylic acid cycle
A	0006102	biological_process	isocitrate metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
B	0000287	molecular_function	magnesium ion binding
B	0006099	biological_process	tricarboxylic acid cycle
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0051287	molecular_function	NAD binding
C	0000287	molecular_function	magnesium ion binding
C	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005975	biological_process	carbohydrate metabolic process
C	0006099	biological_process	tricarboxylic acid cycle
C	0006102	biological_process	isocitrate metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
C	0046872	molecular_function	metal ion binding
C	0051287	molecular_function	NAD binding
D	0000287	molecular_function	magnesium ion binding
D	0006099	biological_process	tricarboxylic acid cycle
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0051287	molecular_function	NAD binding
E	0000287	molecular_function	magnesium ion binding
E	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005975	biological_process	carbohydrate metabolic process
E	0006099	biological_process	tricarboxylic acid cycle
E	0006102	biological_process	isocitrate metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
E	0046872	molecular_function	metal ion binding
E	0051287	molecular_function	NAD binding
F	0000287	molecular_function	magnesium ion binding
F	0006099	biological_process	tricarboxylic acid cycle
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0051287	molecular_function	NAD binding
G	0000287	molecular_function	magnesium ion binding
G	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005975	biological_process	carbohydrate metabolic process
G	0006099	biological_process	tricarboxylic acid cycle
G	0006102	biological_process	isocitrate metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
G	0046872	molecular_function	metal ion binding
G	0051287	molecular_function	NAD binding
H	0000287	molecular_function	magnesium ion binding
H	0006099	biological_process	tricarboxylic acid cycle
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue NAD A 401

Chain	Residue
A	ILE15
A	THR265
A	ALA266
A	ASP268
A	ILE269
A	ASN276
A	ASP317
B	ASN186
B	ILE215
B	ASN218
A	LYS69
A	PRO71
A	LEU72
A	THR74
A	ASN84
A	GLU260
A	HIS263
A	GLY264

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PG4 B 401

Chain	Residue
B	HIS82
B	THR83
B	MET85
B	PRO276

---

site_id	AC3
Number of Residues	17
Details	binding site for residue NAD C 401

Chain	Residue
C	LYS69
C	PRO71
C	LEU72
C	THR74
C	ASN84
C	GLU260
C	SER261
C	HIS263
C	GLY264
C	THR265
C	ALA266
C	ASP268
C	ILE269
C	ASN276
D	ASN186
D	ILE215
D	ASN218

---

site_id	AC4
Number of Residues	6
Details	binding site for residue 2PE D 401

Chain	Residue
D	HIS82
D	THR83
D	PRO84
D	GLU90
D	PRO276
D	PG4402

---

site_id	AC5
Number of Residues	4
Details	binding site for residue PG4 D 402

Chain	Residue
D	ASP23
D	GLY24
D	GLN55
D	2PE401

---

site_id	AC6
Number of Residues	17
Details	binding site for residue NAD E 401

Chain	Residue
E	ILE15
E	LYS69
E	PRO71
E	LEU72
E	THR74
E	ASN84
E	GLU260
E	SER261
E	VAL262
E	HIS263
E	GLY264
E	THR265
E	ALA266
E	ILE269
E	ASN276
F	ILE215
F	ASN218

---

site_id	AC7
Number of Residues	4
Details	binding site for residue PE7 F 401

Chain	Residue
F	HIS82
F	THR83
F	MET85
F	PRO276

---

site_id	AC8
Number of Residues	16
Details	binding site for residue NAD G 401

Chain	Residue
G	ILE15
G	LYS69
G	PRO71
G	LEU72
G	THR74
G	ASN84
G	GLU260
G	HIS263
G	GLY264
G	THR265
G	ALA266
G	ASP268
G	ILE269
G	ASN276
H	ASN186
H	ASN218

---

site_id	AC9
Number of Residues	3
Details	binding site for residue P6G H 401

Chain	Residue
H	VAL54
H	HIS82
H	THR83

---

Functional Information from PROSITE/UniProt

site_id	PS00470
Number of Residues	20
Details	IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLYGDIlSDlcAgli.GGLGV

Chain	Residue	Details
A	ASN226-VAL245
B	ASN237-VAL256

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28098230","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Site: {"description":"Critical for catalysis","evidences":[{"source":"PubMed","id":"28098230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28139779","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Critical for catalysis","evidences":[{"source":"PubMed","id":"28098230","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9D6R2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9D6R2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D6R2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9D6R2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---