6KDX
Crystal structure of PDE10A in complex with a triazolopyrimidine inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 345 | 39606.4 | 2 | UniProt (Q9Y233) In PDB | Homo sapiens (Human) | |
2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A | N-[2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)ethyl]quinolin-2-amine | non-polymer | 318.4 | 1 | Chemie (D6X) | |||
5 | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A, B: 449 - 789 (UniProt: Q9Y233)
PDB | External Database | Details |
---|---|---|
Gly 445 | - | expression tag |
Ser 446 | - | expression tag |
His 447 | - | expression tag |
Met 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 79212.9 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 497.8 | |
All* | Total formula weight | 79710.7 |