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6KDX

Crystal structure of PDE10A in complex with a triazolopyrimidine inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
B0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
B0007165biological_processsignal transduction
B0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue ZN A 801
ChainResidue
AHIS529
AHIS563
AASP564
AASP674
AHOH903
AHOH907

site_idAC2
Number of Residues7
Detailsbinding site for residue MG A 802
ChainResidue
AHOH903
AHOH906
AHOH908
AHOH910
AASP564
AGLU592
ATHR633

site_idAC3
Number of Residues4
Detailsbinding site for residue D6X A 803
ChainResidue
ATYR693
AMET713
AGLN726
APHE729

site_idAC4
Number of Residues7
Detailsbinding site for residue ZN B 801
ChainResidue
BHIS529
BHIS563
BASP564
BASP674
BMG802
BHOH907
BHOH909

site_idAC5
Number of Residues7
Detailsbinding site for residue MG B 802
ChainResidue
BASP564
BZN801
BHOH901
BHOH902
BHOH903
BHOH906
BHOH907

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY
ChainResidueDetails
AHIS563-TYR574

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
ChainResidueDetails
ACYS562
AGLU606
AGLY640
AGLN659
BCYS562
BGLU606
BGLY640
BGLN659

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PDB entries from 2024-05-01

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