6KDT
Crystal structure of human DNMT3B (Q772R)-DNMT3L complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | DNA (cytosine-5)-methyltransferase 3B | polymer | 286 | 32744.9 | 2 | UniProt (Q9UBC3) Pfam (PF00145) In PDB | Homo sapiens (Human) | Dnmt3b,DNA methyltransferase HsaIIIB,M.HsaIIIB |
2 | B, C | DNA (cytosine-5)-methyltransferase 3-like | polymer | 204 | 23627.1 | 2 | UniProt (Q9UJW3) In PDB | Homo sapiens (Human) | |
3 | A, D | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
4 | A, D | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
5 | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A, D: 571 - 853 (UniProt: Q9UBC3)
B, C: 178 - 379 (UniProt: Q9UJW3)
PDB | External Database | Details |
---|---|---|
Gly 568 | - | expression tag |
His 569 | - | expression tag |
Met 570 | - | expression tag |
Arg 772 | Gln 772 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 176 | - | expression tag |
His 177 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 112744.1 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 860.9 | |
All* | Total formula weight | 113604.9 |