6KDR

Crystal structure of human NRMT2 in complex with human centromere protein B peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Alpha N-terminal protein methyltransferase 1B	polymer	244	27519.5	2	UniProt (Q5VVY1) Pfam (PF05891)	Homo sapiens (Human)	Methyltransferase-like protein 11B,X-Pro-Lys N-terminal protein methyltransferase 1B,NTM1B
2	C, D (D, E)	Peptide from Major centromere autoantigen B	polymer	9	1105.3	2	UniProt (P07199)	Homo sapiens	Centromere protein B,CENP-B
3	E, H (A, B)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
4	F, I, J (A, B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
5	G, K, L (A, B, E)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
6	M, N, O, P (A, B, D, E)	water	water		18.0	246	Chemie (HOH)

Sequence modifications

A, B: 61 - 283 (UniProt: Q5VVY1)

PDB	External Database	Details
Met 40	-	expression tag
Gly 41	-	expression tag
Ser 42	-	expression tag
Ser 43	-	expression tag
His 44	-	expression tag
His 45	-	expression tag
His 46	-	expression tag
His 47	-	expression tag
His 48	-	expression tag
His 49	-	expression tag
Ser 50	-	expression tag
Ser 51	-	expression tag
Gly 52	-	expression tag
Leu 53	-	expression tag
Val 54	-	expression tag
Pro 55	-	expression tag
Arg 56	-	expression tag
Gly 57	-	expression tag
Ser 58	-	expression tag
His 59	-	expression tag
Met 60	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	57249.6
Non-Polymers*	Number of molecules	8
	Total formula weight	1151.5
All*	Total formula weight	58401.0

*Water molecules are not included.