6KDE

Crystal structure of the alpha beta heterodimer of human IDH3 in complex with Ca(2+)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	polymer	341	36826.3	2	UniProt (P50213) Pfam (PF00180)	Homo sapiens (Human)	Isocitric dehydrogenase subunit alpha,NAD(+)-specific ICDH subunit alpha
2	B, D (B, D)	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	polymer	356	39703.7	2	UniProt (O43837) Pfam (PF00180)	Homo sapiens (Human)	Isocitric dehydrogenase subunit beta,NAD(+)-specific ICDH subunit beta
3	E, F (A, C)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)

Sequence modifications

A, C: 1 - 339 (UniProt: P50213)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

B, D: 1 - 340 (UniProt: O43837)

PDB	External Database	Details
Glu 341	-	expression tag
Ile 342	-	expression tag
Cys 343	-	expression tag
Arg 344	-	expression tag
Arg 345	-	expression tag
Val 346	-	expression tag
Lys 347	-	expression tag
Asp 348	-	expression tag
Leu 349	-	expression tag
Asp 350	-	expression tag
Glu 351	-	expression tag
Asn 352	-	expression tag
Leu 353	-	expression tag
Tyr 354	-	expression tag
Phe 355	-	expression tag
Gln 356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	153059.9
Non-Polymers*	Number of molecules	2
	Total formula weight	80.2
All*	Total formula weight	153140.1

*Water molecules are not included.