6KDE

Crystal structure of the alpha beta heterodimer of human IDH3 in complex with Ca(2+)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005975	biological_process	carbohydrate metabolic process
A	0006099	biological_process	tricarboxylic acid cycle
A	0006102	biological_process	isocitrate metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
B	0000287	molecular_function	magnesium ion binding
B	0006099	biological_process	tricarboxylic acid cycle
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0051287	molecular_function	NAD binding
C	0000287	molecular_function	magnesium ion binding
C	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005975	biological_process	carbohydrate metabolic process
C	0006099	biological_process	tricarboxylic acid cycle
C	0006102	biological_process	isocitrate metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
C	0046872	molecular_function	metal ion binding
C	0051287	molecular_function	NAD binding
D	0000287	molecular_function	magnesium ion binding
D	0006099	biological_process	tricarboxylic acid cycle
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CA A 401

Chain	Residue
A	ASP230
A	ASP234
B	ASP217

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site_id	AC2
Number of Residues	3
Details	binding site for residue CA C 401

Chain	Residue
C	ASP230
C	ASP234
D	ASP217

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Functional Information from PROSITE/UniProt

site_id	PS00470
Number of Residues	20
Details	IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLYGDIlSDlcAgli.GGLGV

Chain	Residue	Details
A	ASN226-VAL245
B	ASN237-VAL256

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS165
C	ASP206
C	ASP230
C	ASP234
D	LYS165
A	ARG119
A	ASP206
A	ASP230
A	ASP234
C	ARG88
C	ARG98
C	ARG119

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Critical for catalysis => ECO:0000269|PubMed:28098230, ECO:0000269|PubMed:28139779

Chain	Residue	Details
A	TYR126
C	TYR126

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Critical for catalysis => ECO:0000269|PubMed:28098230

Chain	Residue	Details
A	LYS173
C	LYS173

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9D6R2

Chain	Residue	Details
A	LYS50
A	LYS323
C	LYS50
C	LYS323

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9D6R2

Chain	Residue	Details
A	THR74
C	THR74

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9D6R2

Chain	Residue	Details
A	LYS196
C	LYS196

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site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9D6R2

Chain	Residue	Details
A	LYS316
C	LYS316

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