6KDA

Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpG site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	DNA (cytosine-5)-methyltransferase 3B	polymer	286	32715.9	2	UniProt (Q9UBC3) Pfam (PF00145) In PDB	Homo sapiens (Human)	Dnmt3b,DNA methyltransferase HsaIIIB,M.HsaIIIB
2	B, C	DNA (cytosine-5)-methyltransferase 3-like	polymer	204	23627.1	2	UniProt (Q9UJW3) In PDB	Homo sapiens (Human)
3	E, F	DNA (25-MER)	polymer	25	7696.0	2		synthetic construct
4	A, D	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
5		water	water		18.0	305	Chemie (HOH)

Sequence modifications

A, D: 571 - 853 (UniProt: Q9UBC3)

PDB	External Database	Details
Gly 568	-	expression tag
His 569	-	expression tag
Met 570	-	expression tag

B, C: 178 - 379 (UniProt: Q9UJW3)

PDB	External Database	Details
Gly 176	-	expression tag
His 177	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	128077.9
Non-Polymers*	Number of molecules	2
	Total formula weight	768.8
All*	Total formula weight	128846.8

*Water molecules are not included.