6KBF
Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lysine--tRNA ligase | polymer | 516 | 59781.1 | 2 | UniProt (W7JP72) Pfam (PF01336) Pfam (PF00152) | Plasmodium falciparum (isolate NF54) | Lysyl-tRNA synthetase |
| 2 | C, H (A, B) | LYSINE | non-polymer | 147.2 | 2 | Chemie (LYS) | |||
| 3 | D, I (A, B) | (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydro-2~{H}-isoquinolin-1-one | non-polymer | 289.4 | 2 | Chemie (D4X) | |||
| 4 | E, F, G, J, K (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | L (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | M, N (A, B) | water | water | 18.0 | 660 | Chemie (HOH) |
Sequence modifications
A, B: 77 - 583 (UniProt: W7JP72)
| PDB | External Database | Details |
|---|---|---|
| Met 76 | - | initiating methionine |
| Gly 584 | - | expression tag |
| Gly 585 | - | expression tag |
| His 586 | - | expression tag |
| His 587 | - | expression tag |
| His 588 | - | expression tag |
| His 589 | - | expression tag |
| His 590 | - | expression tag |
| His 591 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 119562.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1411.7 | |
| All* | Total formula weight | 120974.0 |
