6KBF
Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004824 | molecular_function | lysine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006430 | biological_process | lysyl-tRNA aminoacylation |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004824 | molecular_function | lysine-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006430 | biological_process | lysyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue LYS A 601 |
| Chain | Residue |
| A | GLY284 |
| A | GLU507 |
| A | GLY552 |
| A | D4X602 |
| A | HOH725 |
| A | ALA285 |
| A | ALA306 |
| A | GLU308 |
| A | ARG330 |
| A | GLU346 |
| A | TYR348 |
| A | ASN503 |
| A | TYR505 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue D4X A 602 |
| Chain | Residue |
| A | ARG330 |
| A | GLU332 |
| A | THR337 |
| A | HIS338 |
| A | ASN339 |
| A | PHE342 |
| A | GLU500 |
| A | LEU502 |
| A | GLY554 |
| A | ARG559 |
| A | ILE570 |
| A | LYS601 |
| A | HOH888 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | LYS321 |
| A | TRP349 |
| A | ALA350 |
| A | TYR351 |
| A | HOH739 |
| A | HOH865 |
| B | LYS105 |
| B | GLU107 |
| B | HOH720 |
| B | HOH803 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 604 |
| Chain | Residue |
| A | ILE258 |
| A | ARG262 |
| A | ILE325 |
| A | HOH962 |
| B | ARG262 |
| B | GLU272 |
| B | GLU274 |
| B | GOL604 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 605 |
| Chain | Residue |
| A | TYR354 |
| A | ASN355 |
| A | HIS482 |
| A | ARG483 |
| A | GLU490 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue LYS B 601 |
| Chain | Residue |
| B | GLY284 |
| B | ALA285 |
| B | GLU308 |
| B | ARG330 |
| B | GLU346 |
| B | TYR348 |
| B | ASN503 |
| B | TYR505 |
| B | GLU507 |
| B | GLY552 |
| B | GLY554 |
| B | HOH719 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue D4X B 602 |
| Chain | Residue |
| B | ARG330 |
| B | GLU332 |
| B | HIS338 |
| B | ASN339 |
| B | PHE342 |
| B | VAL501 |
| B | LEU502 |
| B | GLY554 |
| B | ARG559 |
| B | ILE570 |
| B | HOH755 |
| B | HOH802 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue GOL B 603 |
| Chain | Residue |
| A | LYS105 |
| A | GLU107 |
| A | HOH721 |
| A | HOH833 |
| B | LYS321 |
| B | TRP349 |
| B | ALA350 |
| B | TYR351 |
| B | HOH724 |
| B | HOH813 |
| B | HOH857 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 604 |
| Chain | Residue |
| A | ARG262 |
| A | GLU272 |
| A | GLU274 |
| A | GOL604 |
| B | ILE258 |
| B | ARG262 |
| B | ILE325 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue DMS B 605 |
| Chain | Residue |
| A | PHE271 |
| B | ARG248 |
