6K9V

Crystal structure of tubulin in complex with inhibitor D64

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Tubulin alpha-1B chain	polymer	450	50041.3	2	UniProt (P81947) Pfam (PF00091) Pfam (PF03953) In PDB	Bos taurus (Bovine)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
2	B, D	Tubulin beta-2B chain	polymer	445	49999.9	2	UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) In PDB	Bos taurus (Bovine)
3	E	Stathmin-4	polymer	143	16844.2	1	UniProt (P63043) Pfam (PF00836) In PDB	Rattus norvegicus (Rat)	Stathmin-like protein B3,RB3
4	F	Tubulin tyrosine ligase	polymer	384	44378.5	1	UniProt (E1BQ43) In PDB	Gallus gallus (Chicken)
5	A, C, D	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	3	Chemie (GTP)
6	A, B, C, D	MAGNESIUM ION	non-polymer		24.3	5	Chemie (MG)
7	B	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
8	B	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES)
9	B, D	(5-methoxy-1H-indol-2-yl)-phenyl-methanone	non-polymer		251.3	2	Chemie (D3L)
10	C	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
11	F	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)
12		water	water		18.0	426	Chemie (HOH)

Sequence modifications

E: 5 - 145 (UniProt: P63043)

PDB	External Database	Details
Met 3	-	expression tag
Ala 4	-	expression tag

F: 1 - 378 (UniProt: E1BQ43)

PDB	External Database	Details
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	261305.0
Non-Polymers*	Number of molecules	14
	Total formula weight	3377.3
All*	Total formula weight	264682.3

*Water molecules are not included.