6K7I
Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state class2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phospholipid-transporting ATPase | polymer | 1154 | 130537.9 | 1 | UniProt (Q59EX4) Pfam (PF16209) Pfam (PF00122) Pfam (PF13246) Pfam (PF16212) UniProt (by SIFTS) (Q9Y2Q0) In PDB | Homo sapiens (Human) | |
| 2 | C | Cell cycle control protein 50A | polymer | 361 | 40727.5 | 1 | UniProt (Q9NV96) Pfam (PF03381) In PDB | Homo sapiens (Human) | |
| 3 | B | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 4 | A | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 5 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | C | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) |
Sequence modifications
A: 1 - 1149 (UniProt: Q59EX4)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 171265.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1434.3 | |
| All* | Total formula weight | 173286.3 |
