6K3E
LSD1/Co-Rest structure with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific histone demethylase 1A | polymer | 662 | 73652.2 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | Homo sapiens (human) | BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2 |
| 2 | B (B) | REST corepressor 1 | polymer | 140 | 15850.9 | 1 | UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) | Homo sapiens (human) | Protein CoREST |
| 3 | C (A) | piperidin-4-ylmethyl 4-fluoranyl-4-[[[(1~{R},2~{S})-2-phenylcyclopropyl]amino]methyl]piperidine-1-carboxylate | non-polymer | 389.5 | 1 | Chemie (CW0) | |||
| 4 | D (A) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 5 | E, F (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 6 | G, H, I (A) | MALONIC ACID | non-polymer | 104.1 | 3 | Chemie (MLA) | |||
| 7 | J, K, L, M (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 8 | N (A) | 2-PCPA derivative | non-polymer | 901.7 | 1 | Chemie (D3U) | |||
| 9 | O, P, Q, R, S... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
| 10 | AA, BA, CA (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 11 | DA, EA (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 12 | FA (A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
B: 308 - 440 (UniProt: Q9UKL0)
| PDB | External Database | Details |
|---|---|---|
| Gly 301 | - | expression tag |
| Ser 302 | - | expression tag |
| Ser 303 | - | expression tag |
| Gly 304 | - | expression tag |
| Ser 305 | - | expression tag |
| Ala 306 | - | expression tag |
| Ser 307 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 89503.2 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 3378.2 | |
| All* | Total formula weight | 92881.4 |
