6K0T
Crystal Structure of PPARgamma Ligand Binding Domain in complex with dibenzooxepine derivative compound-17
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Peroxisome proliferator-activated receptor gamma | polymer | 287 | 32769.9 | 2 | UniProt (P37231) Pfam (PF00104) In PDB | Homo sapiens (Human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 2 | B, D | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 12 | 1355.7 | 2 | UniProt (by SIFTS) (Q9UBK2) In PDB | Homo sapiens | |
| 3 | A, C | 3-[(1~{E})-1-[8-[(8-chloranyl-2-cyclopropyl-imidazo[1,2-a]pyridin-3-yl)methyl]-3-fluoranyl-6~{H}-benzo[c][1]benzoxepin-11-ylidene]ethyl]-4~{H}-1,2,4-oxadiazol-5-one | non-polymer | 529.0 | 2 | Chemie (CTU) | |||
| 4 | water | water | 18.0 | 449 | Chemie (HOH) |
Sequence modifications
A, C: 195 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Gly 191 | - | expression tag |
| Ser 192 | - | expression tag |
| His 193 | - | expression tag |
| Met 194 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 68251.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1057.9 | |
| All* | Total formula weight | 69309.1 |
