6K0T

Crystal Structure of PPARgamma Ligand Binding Domain in complex with dibenzooxepine derivative compound-17

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue CTU A 501

Chain	Residue
A	PHE282
A	PHE363
A	MET364
A	HIS449
A	LEU452
A	ILE456
A	MET463
A	TYR473
A	HOH738
A	GLN283
A	CME285
A	SER289
A	HIS323
A	ILE326
A	TYR327
A	ILE341
A	PHE360

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site_id	AC2
Number of Residues	17
Details	binding site for residue CTU C 501

Chain	Residue
C	PHE282
C	GLN283
C	CME285
C	GLN286
C	SER289
C	HIS323
C	ILE326
C	TYR327
C	LEU353
C	PHE360
C	MET364
C	HIS449
C	LEU452
C	ILE456
C	MET463
C	TYR473
C	HOH730

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O70343

Chain	Residue	Details
B	LYS146
D	LYS146
A	HIS449
A	TYR473
C	GLN286
C	HIS323
C	HIS449
C	TYR473

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649

Chain	Residue	Details
A	LYS224
C	LYS224

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