6JYQ
Crystal structure of uPA_H99Y in complex with 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | U | Urokinase-type plasminogen activator | polymer | 246 | 27740.6 | 1 | UniProt (P00749) Pfam (PF00089) In PDB | Homo sapiens (Human) | uPA |
| 2 | U | 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide | non-polymer | 343.4 | 1 | Chemie (EAU) | |||
| 3 | U | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
U: 16 - 243 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Tyr 99 | His 272 | engineered mutation |
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27740.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 439.4 | |
| All* | Total formula weight | 28180.1 |
