6JWT
Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with Pteroate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase | polymer | 728 | 86033.6 | 2 | UniProt (Q25704) Pfam (PF01288) Pfam (PF00809) In PDB | Plasmodium falciparum | Dihydropteroate synthetase |
2 | A | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
4 | A, B | PTEROIC ACID | non-polymer | 312.3 | 2 | Chemie (PT1) | |||
5 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
6 | A, B | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
7 | B | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
8 | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 706 (UniProt: Q25704)
PDB | External Database | Details |
---|---|---|
Phe 436 | Ser 436 | engineered mutation |
Gly 437 | Ala 437 | engineered mutation |
Thr 613 | Ala 613 | engineered mutation |
Lys 707 | - | expression tag |
Asp 708 | - | expression tag |
Pro 709 | - | expression tag |
Asn 710 | - | expression tag |
Ser 711 | - | expression tag |
Ser 712 | - | expression tag |
Ser 713 | - | expression tag |
Val 714 | - | expression tag |
Asp 715 | - | expression tag |
Lys 716 | - | expression tag |
Leu 717 | - | expression tag |
Ala 718 | - | expression tag |
Ala 719 | - | expression tag |
Ala 720 | - | expression tag |
Leu 721 | - | expression tag |
Glu 722 | - | expression tag |
His 723 | - | expression tag |
His 724 | - | expression tag |
His 725 | - | expression tag |
His 726 | - | expression tag |
His 727 | - | expression tag |
His 728 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 172067.2 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 1868.2 | |
All* | Total formula weight | 173935.4 |