6JWT
Crystal structure of Plasmodium falciparum HPPK-DHPS S436F/A437G/A613T triple mutant with Pteroate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
A | 0004156 | molecular_function | dihydropteroate synthase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0042558 | biological_process | pteridine-containing compound metabolic process |
A | 0044237 | biological_process | cellular metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046656 | biological_process | folic acid biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
B | 0004156 | molecular_function | dihydropteroate synthase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0042558 | biological_process | pteridine-containing compound metabolic process |
B | 0044237 | biological_process | cellular metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046656 | biological_process | folic acid biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | binding site for residue AMP A 801 |
Chain | Residue |
A | LEU181 |
A | SER317 |
A | ILE318 |
A | HIS320 |
A | MG802 |
A | MG803 |
A | HOH912 |
A | HOH968 |
A | LYS185 |
A | ASP210 |
A | ILE211 |
A | ASN312 |
A | ILE313 |
A | GLU314 |
A | PHE315 |
A | LEU316 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MG A 802 |
Chain | Residue |
A | ASP208 |
A | ASP210 |
A | AMP801 |
A | MG803 |
A | HOH912 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue MG A 803 |
Chain | Residue |
A | AMP801 |
A | MG802 |
A | HOH968 |
site_id | AC4 |
Number of Residues | 17 |
Details | binding site for residue PT1 A 804 |
Chain | Residue |
A | GLY437 |
A | PRO438 |
A | ASP482 |
A | ASN502 |
A | ILE504 |
A | MET529 |
A | ASP575 |
A | GLY579 |
A | PHE580 |
A | PHE603 |
A | GLY605 |
A | LYS609 |
A | ARG610 |
A | ARG686 |
A | ACT807 |
A | HOH925 |
A | HOH956 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue CA A 805 |
Chain | Residue |
A | GLU42 |
A | GLY46 |
A | GLU99 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue ACT A 806 |
Chain | Residue |
A | HIS530 |
A | ARG532 |
A | ASP550 |
A | TYR554 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue ACT A 807 |
Chain | Residue |
A | ARG686 |
A | HIS688 |
A | PT1804 |
site_id | AC8 |
Number of Residues | 11 |
Details | binding site for residue ATP B 801 |
Chain | Residue |
B | LEU181 |
B | ASP208 |
B | ASP210 |
B | ILE211 |
B | ASN312 |
B | PHE315 |
B | LEU316 |
B | SER317 |
B | HIS320 |
B | MG802 |
B | HOH903 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue MG B 802 |
Chain | Residue |
B | ASP208 |
B | ASP210 |
B | ATP801 |
B | HOH903 |
site_id | AD1 |
Number of Residues | 17 |
Details | binding site for residue PT1 B 803 |
Chain | Residue |
B | GLY437 |
B | PRO438 |
B | ASP482 |
B | ASN502 |
B | ILE504 |
B | MET529 |
B | ASP575 |
B | GLY579 |
B | PHE580 |
B | PHE603 |
B | GLY605 |
B | LYS609 |
B | ARG610 |
B | ARG686 |
B | ACT806 |
B | HOH908 |
B | HOH938 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue CA B 804 |
Chain | Residue |
B | GLU42 |
B | GLY46 |
B | GLU99 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue ACT B 805 |
Chain | Residue |
A | ASN487 |
A | ASN510 |
A | HOH947 |
B | HIS530 |
B | ARG532 |
B | HOH933 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue ACT B 806 |
Chain | Residue |
B | ASN396 |
B | ARG686 |
B | HIS688 |
B | PT1803 |
B | HOH929 |