6JPJ
Crystal structure of FGF401 in complex of FGFR4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Fibroblast growth factor receptor 4 | polymer | 311 | 34663.0 | 1 | UniProt (P22455) Pfam (PF07714) In PDB | Homo sapiens (Human) | FGFR-4 |
| 2 | A | N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide | non-polymer | 506.6 | 1 | Chemie (FGF) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A: 445 - 753 (UniProt: P22455)
| PDB | External Database | Details |
|---|---|---|
| Gly 443 | - | expression tag |
| Pro 444 | - | expression tag |
| Ala 477 | Cys 477 | engineered mutation |
| Glu 664 | Arg 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34663.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 698.7 | |
| All* | Total formula weight | 35361.7 |
