6JOK
Crystal structure of PDGFRA in complex with sunitinib by soaking
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Platelet-derived growth factor receptor alpha | polymer | 356 | 40588.7 | 1 | UniProt (P16234) Pfam (PF07714) | Homo sapiens (Human) | PDGFR-alpha,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140a antigen,Platelet-derived growth factor alpha receptor,Platelet-derived growth factor receptor 2,PDGFR-2 |
| 2 | B (A) | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide | non-polymer | 398.5 | 1 | Chemie (B49) | |||
| 3 | C, D (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | E (A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 550 - 696 (UniProt: P16234)
A: 769 - 973 (UniProt: P16234)
| PDB | External Database | Details |
|---|---|---|
| Gly 546 | - | expression tag |
| Ala 547 | - | expression tag |
| Met 548 | - | expression tag |
| Asp 549 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40588.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 469.4 | |
| All* | Total formula weight | 41058.1 |
