6JOI

Crystal structure of PDGFRA T674I in complex with crenolanib by co-crystallization

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Platelet-derived growth factor receptor alpha	polymer	375	43030.3	1	UniProt (P16234) Pfam (PF07714)	Homo sapiens (Human)	PDGFR-alpha,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140a antigen,Platelet-derived growth factor alpha receptor,Platelet-derived growth factor receptor 2,PDGFR-2
2	B (A)	1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine	non-polymer		443.5	1	Chemie (6T2)
3	C (A)	water	water		18.0	16	Chemie (HOH)

Sequence modifications

A: 550 - 768 (UniProt: P16234)

PDB	External Database	Details
His 527	-	expression tag
His 528	-	expression tag
His 529	-	expression tag
His 530	-	expression tag
His 531	-	expression tag
His 532	-	expression tag
Asp 533	-	expression tag
Tyr 534	-	expression tag
Asp 535	-	expression tag
Ile 536	-	expression tag
Pro 537	-	expression tag
Thr 538	-	expression tag
Thr 539	-	expression tag
Glu 540	-	expression tag
Asn 541	-	expression tag
Leu 542	-	expression tag
Tyr 543	-	expression tag
Phe 544	-	expression tag
Gln 545	-	expression tag
Gly 546	-	expression tag
Ala 547	-	expression tag
Met 548	-	expression tag
Asp 549	-	expression tag
Ile 674	Thr 674	engineered mutation

A: 769 - 973 (UniProt: P16234)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43030.3
Non-Polymers*	Number of molecules	1
	Total formula weight	443.5
All*	Total formula weight	43473.9

*Water molecules are not included.