6JMQ

LAT1-CD98hc complex bound to MEM-108 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Large neutral amino acids transporter small subunit 1	polymer	515	56043.7	1	UniProt (Q01650) Pfam (PF13520) In PDB	Homo sapiens (Human)	4F2 light chain,4F2LC,CD98 light chain,Integral membrane protein E16,L-type amino acid transporter 1,hLAT1,Solute carrier family 7 member 5,y+ system cationic amino acid transporter
2	B	4F2 cell-surface antigen heavy chain	polymer	631	68069.6	1	UniProt (P08195) Pfam (PF16028) Pfam (PF00128) In PDB	Homo sapiens (Human)	Glycoprotein, 4F2hc,4F2 heavy chain antigen,Lymphocyte activation antigen 4F2 large subunit,Solute carrier family 3 member 2
3	C	Antibody	polymer	219	22577.9	1		Mus musculus
4	D	Antibody	polymer	219	23227.2	1		Mus musculus
5	E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	A, B	CHOLESTEROL	non-polymer		386.7	5	Chemie (CLR)
7	B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)

Sequence modifications

A: 1 - 507 (UniProt: Q01650)

PDB	External Database	Details
Asp 508	-	expression tag
Tyr 509	-	expression tag
Lys 510	-	expression tag
Asp 511	-	expression tag
Asp 512	-	expression tag
Asp 513	-	expression tag
Asp 514	-	expression tag
Lys 515	-	expression tag

B: 2 - 630 (UniProt: P08195)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	169918.4
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	8
	Total formula weight	2596.9
All*	Total formula weight	172939.7

*Water molecules are not included.