6JMQ
LAT1-CD98hc complex bound to MEM-108 Fab
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002720 | biological_process | positive regulation of cytokine production involved in immune response |
| A | 0003333 | biological_process | amino acid transmembrane transport |
| A | 0005515 | molecular_function | protein binding |
| A | 0005765 | cellular_component | lysosomal membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006865 | biological_process | amino acid transport |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0010507 | biological_process | negative regulation of autophagy |
| A | 0010629 | biological_process | negative regulation of gene expression |
| A | 0014850 | biological_process | response to muscle activity |
| A | 0015171 | molecular_function | amino acid transmembrane transporter activity |
| A | 0015173 | molecular_function | aromatic amino acid transmembrane transporter activity |
| A | 0015175 | molecular_function | neutral L-amino acid transmembrane transporter activity |
| A | 0015179 | molecular_function | L-amino acid transmembrane transporter activity |
| A | 0015190 | molecular_function | L-leucine transmembrane transporter activity |
| A | 0015196 | molecular_function | L-tryptophan transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015349 | molecular_function | thyroid hormone transmembrane transporter activity |
| A | 0015804 | biological_process | neutral amino acid transport |
| A | 0015807 | biological_process | L-amino acid transport |
| A | 0015818 | biological_process | isoleucine transport |
| A | 0015820 | biological_process | L-leucine transport |
| A | 0015821 | biological_process | methionine transport |
| A | 0015823 | biological_process | phenylalanine transport |
| A | 0015824 | biological_process | proline transport |
| A | 0015827 | biological_process | tryptophan transport |
| A | 0015828 | biological_process | tyrosine transport |
| A | 0015829 | biological_process | valine transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0031528 | cellular_component | microvillus membrane |
| A | 0032328 | biological_process | alanine transport |
| A | 0032729 | biological_process | positive regulation of type II interferon production |
| A | 0032740 | biological_process | positive regulation of interleukin-17 production |
| A | 0032753 | biological_process | positive regulation of interleukin-4 production |
| A | 0042149 | biological_process | cellular response to glucose starvation |
| A | 0042605 | molecular_function | peptide antigen binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0055093 | biological_process | response to hyperoxia |
| A | 0060252 | biological_process | positive regulation of glial cell proliferation |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070327 | biological_process | thyroid hormone transport |
| A | 0071222 | biological_process | cellular response to lipopolysaccharide |
| A | 0071230 | biological_process | cellular response to amino acid stimulus |
| A | 0089718 | biological_process | amino acid import across plasma membrane |
| A | 0097421 | biological_process | liver regeneration |
| A | 0098591 | cellular_component | external side of apical plasma membrane |
| A | 0150104 | biological_process | transport across blood-brain barrier |
| A | 1902024 | biological_process | L-histidine transport |
| A | 1902475 | biological_process | L-alpha-amino acid transmembrane transport |
| A | 1903577 | biological_process | cellular response to L-arginine |
| A | 1903801 | biological_process | L-leucine import across plasma membrane |
| A | 1904556 | biological_process | L-tryptophan transmembrane transport |
| A | 1905460 | biological_process | negative regulation of vascular associated smooth muscle cell apoptotic process |
| A | 1905534 | biological_process | positive regulation of L-leucine import across plasma membrane |
| A | 1990184 | cellular_component | amino acid transport complex |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006865 | biological_process | amino acid transport |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| D | TYR198-HIS204 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 241 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 68 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 47 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 424 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"11121428","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19065266","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30867591","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33298890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33758168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34880232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35352032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CMH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EPZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7P9V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
