6JLY

eIF2a - eIF2B complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Translation initiation factor eIF-2B subunit alpha	polymer	341	37817.3	2	UniProt (Q9USP0) Pfam (PF01008) In PDB	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	eIF2Ba,eIF-2B GDP-GTP exchange factor subunit alpha
2	C, D	Probable translation initiation factor eIF-2B subunit beta	polymer	399	43897.9	2	UniProt (Q9UT76) Pfam (PF01008) In PDB	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	eIF2Bb,eIF-2B GDP-GTP exchange factor subunit beta
3	E, F	Probable translation initiation factor eIF-2B subunit gamma	polymer	458	50551.9	2	UniProt (P56288) Pfam (PF00483) In PDB	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	eIF2Bg,eIF-2B GDP-GTP exchange factor subunit gamma
4	G, H	Probable translation initiation factor eIF-2B subunit delta	polymer	467	51652.2	2	UniProt (Q09924) Pfam (PF01008) In PDB	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	eIF2Bd,eIF-2B GDP-GTP exchange factor subunit delta
5	I, J	Probable translation initiation factor eIF-2B subunit epsilon	polymer	678	76413.5	2	UniProt (P56287) Pfam (PF00483) Pfam (PF00132) Pfam (PF02020) In PDB	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	eIF2Be,eIF-2B GDP-GTP exchange factor subunit epsilon
6	L, M	Eukaryotic translation initiation factor 2 subunit alpha	polymer	304	34763.7	2	UniProt (P20459) Pfam (PF00575) Pfam (PF07541) In PDB	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	eIF2a,eIF-2-alpha
7	C, D, E, F, G...	PHOSPHATE ION	non-polymer		95.0	8	Chemie (PO4)

Sequence modifications

C, D: 1 - 393 (UniProt: Q9UT76)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Ile -3	-	expression tag
Ser -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

E, F: 1 - 458 (UniProt: P56288)

PDB	External Database	Details
Tyr 157	Ile 157	conflict
Thr 158	Tyr 158	conflict
Val 159	Gly 159	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	590192.9
Non-Polymers*	Number of molecules	8
	Total formula weight	759.8
All*	Total formula weight	590952.6

*Water molecules are not included.