Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6JLY

eIF2a - eIF2B complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002183	biological_process	cytoplasmic translational initiation
A	0003743	molecular_function	translation initiation factor activity
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0030234	molecular_function	enzyme regulator activity
A	1904262	biological_process	negative regulation of TORC1 signaling
B	0002183	biological_process	cytoplasmic translational initiation
B	0003743	molecular_function	translation initiation factor activity
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0030234	molecular_function	enzyme regulator activity
B	1904262	biological_process	negative regulation of TORC1 signaling
C	0002183	biological_process	cytoplasmic translational initiation
C	0003743	molecular_function	translation initiation factor activity
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0006417	biological_process	regulation of translation
C	0030234	molecular_function	enzyme regulator activity
D	0002183	biological_process	cytoplasmic translational initiation
D	0003743	molecular_function	translation initiation factor activity
D	0005085	molecular_function	guanyl-nucleotide exchange factor activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0006417	biological_process	regulation of translation
D	0030234	molecular_function	enzyme regulator activity
E	0002183	biological_process	cytoplasmic translational initiation
E	0003743	molecular_function	translation initiation factor activity
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0009058	biological_process	biosynthetic process
F	0002183	biological_process	cytoplasmic translational initiation
F	0003743	molecular_function	translation initiation factor activity
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0009058	biological_process	biosynthetic process
G	0002183	biological_process	cytoplasmic translational initiation
G	0003743	molecular_function	translation initiation factor activity
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0005515	molecular_function	protein binding
G	0005829	cellular_component	cytosol
G	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
G	0006412	biological_process	translation
G	0006413	biological_process	translational initiation
H	0002183	biological_process	cytoplasmic translational initiation
H	0003743	molecular_function	translation initiation factor activity
H	0005085	molecular_function	guanyl-nucleotide exchange factor activity
H	0005515	molecular_function	protein binding
H	0005829	cellular_component	cytosol
H	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
H	0006412	biological_process	translation
H	0006413	biological_process	translational initiation
I	0002183	biological_process	cytoplasmic translational initiation
I	0003743	molecular_function	translation initiation factor activity
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0005515	molecular_function	protein binding
I	0005829	cellular_component	cytosol
I	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
I	0006412	biological_process	translation
I	0006413	biological_process	translational initiation
I	0009058	biological_process	biosynthetic process
I	0031369	molecular_function	translation initiation factor binding
J	0002183	biological_process	cytoplasmic translational initiation
J	0003743	molecular_function	translation initiation factor activity
J	0005085	molecular_function	guanyl-nucleotide exchange factor activity
J	0005515	molecular_function	protein binding
J	0005829	cellular_component	cytosol
J	0005851	cellular_component	eukaryotic translation initiation factor 2B complex
J	0006412	biological_process	translation
J	0006413	biological_process	translational initiation
J	0009058	biological_process	biosynthetic process
J	0031369	molecular_function	translation initiation factor binding
L	0001731	biological_process	formation of translation preinitiation complex
L	0003676	molecular_function	nucleic acid binding
L	0003723	molecular_function	RNA binding
L	0003743	molecular_function	translation initiation factor activity
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005840	cellular_component	ribosome
L	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
L	0006412	biological_process	translation
L	0006413	biological_process	translational initiation
L	0010494	cellular_component	cytoplasmic stress granule
L	0033290	cellular_component	eukaryotic 48S preinitiation complex
L	0043022	molecular_function	ribosome binding
L	0043614	cellular_component	multi-eIF complex
L	1990856	molecular_function	methionyl-initiator methionine tRNA binding
M	0001731	biological_process	formation of translation preinitiation complex
M	0003676	molecular_function	nucleic acid binding
M	0003723	molecular_function	RNA binding
M	0003743	molecular_function	translation initiation factor activity
M	0005515	molecular_function	protein binding
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005840	cellular_component	ribosome
M	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
M	0006412	biological_process	translation
M	0006413	biological_process	translational initiation
M	0010494	cellular_component	cytoplasmic stress granule
M	0033290	cellular_component	eukaryotic 48S preinitiation complex
M	0043022	molecular_function	ribosome binding
M	0043614	cellular_component	multi-eIF complex
M	1990856	molecular_function	methionyl-initiator methionine tRNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue PO4 C 401

Chain	Residue
C	PRO28
C	SER211
C	LYS212
C	LYS315

site_id	AC2
Number of Residues	4
Details	binding site for residue PO4 D 401

Chain	Residue
D	PRO28
D	LYS212
D	TYR314
D	LYS315

site_id	AC3
Number of Residues	4
Details	binding site for residue PO4 E 501

Chain	Residue
E	LYS376
E	SER377
E	ILE378
E	ALA337

site_id	AC4
Number of Residues	3
Details	binding site for residue PO4 E 502

Chain	Residue
E	ASN49
E	SER128
E	ARG263

site_id	AC5
Number of Residues	5
Details	binding site for residue PO4 F 501

Chain	Residue
F	ILE336
F	ALA337
F	LYS376
F	SER377
F	ILE378

site_id	AC6
Number of Residues	2
Details	binding site for residue PO4 F 502

Chain	Residue
F	ASN49
F	ARG263

site_id	AC7
Number of Residues	4
Details	binding site for residue PO4 G 501

Chain	Residue
G	GLY159
G	SER160
G	HIS344
G	TYR432

site_id	AC8
Number of Residues	3
Details	binding site for residue PO4 H 501

Chain	Residue
H	GLY159
H	SER160
H	HIS344

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18257517","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by GCN2","evidences":[{"source":"PubMed","id":"10733573","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1739968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8336737","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)