6JK8
Cryo-EM structure of the full-length human IGF-1R in complex with insulin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Insulin-like growth factor 1 receptor | polymer | 1367 | 154964.5 | 2 | UniProt (P08069) Pfam (PF01030) Pfam (PF00757) Pfam (PF07714) | Homo sapiens (Human) | Insulin-like growth factor I receptor,IGF-I receptor |
| 2 | C, D (C, D) | Insulin | polymer | 110 | 11989.9 | 2 | UniProt (P01308) Pfam (PF00049) | Homo sapiens (Human) | |
| 3 | E, G, H, I (E, G, H, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 4 | F (F) | alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81874LD) | |||
| 5 | J, K, L, M, N... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 333908.7 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2446.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1327.2 | |
| All* | Total formula weight | 337682.2 |
