6JK8
Cryo-EM structure of the full-length human IGF-1R in complex with insulin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0043548 | molecular_function | phosphatidylinositol 3-kinase binding |
| A | 0043560 | molecular_function | insulin receptor substrate binding |
| A | 0046777 | biological_process | protein autophosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
| B | 0043548 | molecular_function | phosphatidylinositol 3-kinase binding |
| B | 0043560 | molecular_function | insulin receptor substrate binding |
| B | 0046777 | biological_process | protein autophosphorylation |
| C | 0005179 | molecular_function | hormone activity |
| C | 0005576 | cellular_component | extracellular region |
| D | 0005179 | molecular_function | hormone activity |
| D | 0005576 | cellular_component | extracellular region |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGvakgvvkdepetr.....VAIK |
| Chain | Residue | Details |
| A | LEU1006-LYS1034 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCMV |
| Chain | Residue | Details |
| A | PHE1132-VAL1144 |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYetdYYR |
| Chain | Residue | Details |
| A | ASP1160-ARG1168 |
| site_id | PS00262 |
| Number of Residues | 15 |
| Details | INSULIN Insulin family signature. CCTSiCSlyqLenyC |
| Chain | Residue | Details |
| C | CYS6-CYS20 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 388 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP742-HIS936 | |
| B | ASP742-HIS936 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU937-HIS960 | |
| B | LEU937-HIS960 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 814 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG961-CYS1368 | |
| B | ARG961-CYS1368 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 |
| Chain | Residue | Details |
| A | ASP1136 | |
| B | ASP1136 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU1006 | |
| B | LEU1006 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS1034 | |
| B | LYS1034 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:7541045 |
| Chain | Residue | Details |
| A | TYR981 | |
| B | TYR981 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11694888, ECO:0000269|PubMed:18501599, ECO:0000269|PubMed:19041240 |
| Chain | Residue | Details |
| A | TYR1162 | |
| A | TYR1166 | |
| A | TYR1167 | |
| B | TYR1162 | |
| B | TYR1166 | |
| B | TYR1167 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by GSK3-beta => ECO:0000250|UniProtKB:Q60751 |
| Chain | Residue | Details |
| A | SER1279 | |
| B | SER1279 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q60751 |
| Chain | Residue | Details |
| A | SER1283 | |
| B | SER1283 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:9690478 |
| Chain | Residue | Details |
| A | ASN51 | |
| A | ASN135 | |
| A | ASN244 | |
| A | ASN314 | |
| B | ASN51 | |
| B | ASN135 | |
| B | ASN244 | |
| B | ASN314 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 24 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN102 | |
| A | ASN765 | |
| A | ASN901 | |
| A | ASN914 | |
| B | ASN102 | |
| B | ASN417 | |
| B | ASN438 | |
| B | ASN534 | |
| B | ASN607 | |
| B | ASN622 | |
| B | ASN640 | |
| A | ASN417 | |
| B | ASN748 | |
| B | ASN757 | |
| B | ASN765 | |
| B | ASN901 | |
| B | ASN914 | |
| A | ASN438 | |
| A | ASN534 | |
| A | ASN607 | |
| A | ASN622 | |
| A | ASN640 | |
| A | ASN748 | |
| A | ASN757 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21994939 |
| Chain | Residue | Details |
| A | LYS1169 | |
| A | LYS1172 | |
| B | LYS1169 | |
| B | LYS1172 |
